Results
|
Specimen
2A:
embryonic day 6.75
(more )
Specimen
2A:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 6.75
|
Age Note:
|
Theiler stage of this specimen assigned by curators from EMAGE.
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS10: embryo |
Weak |
Regionally restricted |
2A
|
Expression is in scattered cells in the posterior half of the embryo.
|
Specimen
2B:
embryonic day 7.0
(more )
Specimen
2B:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 7.0
|
Age Note:
|
Theiler stage of this specimen assigned by curators from EMAGE.
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS11: node |
Present |
|
2B
|
|
TS11: allantois |
Present |
Regionally restricted |
2B
|
Expression is in the base of the allantois and the extraembryonic mesoderm at the posterior end of the embryo.
|
TS11: extraembryonic mesoderm |
Present |
Regionally restricted |
2B
|
Expression is in the base of the allantois and the extraembryonic mesoderm at the posterior end of the embryo.
|
Specimen
2C:
embryonic day 7.5
(more )
Specimen
2C:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 7.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS11: node |
Present |
|
2C
|
|
TS11: allantois |
Present |
Regionally restricted |
2C
|
Expression is in the base of the allantois and the extraembryonic mesoderm at the posterior end of the embryo.
|
TS11: extraembryonic mesoderm |
Present |
Regionally restricted |
2C
|
Expression is in the base of the allantois and the extraembryonic mesoderm at the posterior end of the embryo.
|
Specimen
2D:
embryonic day 7.75
(more )
Specimen
2D:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 7.75
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS11: heart |
Present |
|
2D
|
|
TS11: embryo |
Present |
Regionally restricted |
2D
|
Expression is in the posterior trunk of the embryo. Expression in the node has gradually disappeared.
|
Specimen
Not shown:
embryonic day 9.5
(more )
Specimen
Not shown:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 9.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS15: heart |
Present |
Regionally restricted |
|
Expression was detected in the myocardial layer.
|
Specimen
2E:
embryonic day 8.25-8.5
(more )
Specimen
2E:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 8.25-8.5
|
Age Note:
|
Theiler stage of this specimen assigned by curators from EMAGE.
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS12: embryo |
Present |
Regionally restricted |
2E
|
Expression in the poserior trunk and tail bud.
|
TS12: heart |
Strong |
|
2E
|
|
TS12: head somite |
Weak |
Regionally restricted |
2E
|
Expression in most rostral somites at the dorsal-most aspect, probably marking the future dermatome.
|
Specimen
2F:
embryonic day 9.0-9.5
(more )
Specimen
2F:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 9.0-9.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Specimen
2G:
embryonic day 9.25-9.5
(more )
Specimen
2G:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 9.25-9.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS15: forelimb bud |
Present |
Regionally restricted |
2G
|
Expression was detected in the distal domain.
|
TS15: nephric duct |
Present |
|
2G
|
Expression accompanies the posterior elongation of the duct.
|
TS15: trunk somite |
Present |
Graded |
2G
|
Expression is weak in newly forming and stronger in more mature somites.
|
TS15: tail |
Present |
|
2G
|
|
TS15: embryo |
Present |
Regionally restricted |
2G
|
Expression is in the posterior trunk of the embryo.
|
Specimen
2H:
embryonic day 10.5
(more )
Specimen
2H:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Specimen
3A:
embryonic day 10.5
(more )
Specimen
3A:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS17: mesonephros |
Strong |
Regionally restricted |
3A
|
Expression is in the epithelium of the ureter adjacent to the metanephritic mesenchyme.
|
Specimen
3B:
embryonic day 10.75
(more )
Specimen
3B:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 10.75
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS18: ureteric bud |
Present |
Regionally restricted |
3B
|
Expression is only detected at the rounded tip of the bud and is absent from the stalk.
|
Specimen
3C:
embryonic day 11.0
(more )
Specimen
3C:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 11.0
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS18: ureteric bud |
Present |
Regionally restricted |
3C
|
Expression is only detected at the rounded tip of the bud and is absent from the stalk.
|
Specimen
3D:
embryonic day 11.5
(more )
Specimen
3D:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 11.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: ureteric bud |
Present |
Regionally restricted |
3D
|
The expression domain splits in two after bifurcation of the ureter. Expression remains at the rounded tip of both branches and is absent from the stalk.
|
Specimen
3E:
embryonic day 16.5
(more )
Specimen
3E:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 16.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Specimen
Not shown:
embryonic day 12.5
(more )
Specimen
Not shown:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Specimen
Not shown:
embryonic day 18.5
(more )
Specimen
Not shown:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 18.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Specimen
3F:
embryonic day 16.5
(more )
Specimen
3F:
(close )
Genetic Background:
|
Swiss Webster
|
Age:
|
embryonic day 16.5
|
Sex:
|
Not Specified
|
Type:
|
section from whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS24: ureter |
Present |
Regionally restricted |
3F
|
Expression was detected in the growing tips in the peripheral nephrogenic region.
|
Specimen
4A:
embryonic day 11.0-11.5; Krt25Re/ Krt25Re, Etn2Sd/Etn2 +
(more )
Note: The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
Specimen
4A:
(close )
Genetic Background:
|
RSV/LeJ
|
Mutant Allele(s):
|
Krt25Re/Krt25Re Etn2Sd/Etn2+
|
Age:
|
embryonic day 11.0-11.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Note:
|
The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: trunk somite |
Present |
Regionally restricted |
4A
|
Expression was absent from the caudal somites.
|
TS19: ureteric bud |
Present |
Regionally restricted |
4A
|
Expression in the tips was as in wild type in 12/26 cases, bilateral but with unequal staining in 5/26 cases and unilateral in 5/26 cases. Expression in the ureter tips was weak or not detected in 4/26 cases.
|
Specimen
4B:
embryonic day 11.0-11.5; Krt25Re/ Krt25Re, Etn2Sd/Etn2 +
(more )
Note: The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
Specimen
4B:
(close )
Genetic Background:
|
RSV/LeJ
|
Mutant Allele(s):
|
Krt25Re/Krt25Re Etn2Sd/Etn2+
|
Age:
|
embryonic day 11.0-11.5
|
Sex:
|
Not Specified
|
Type:
|
section from whole mount
|
Note:
|
The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: trunk somite |
Present |
Regionally restricted |
4B
|
Expression was absent from the caudal somites.
|
TS19: ureteric bud |
Present |
Regionally restricted |
4B
|
Expression in the tips was as in wild type in 12/26 cases, bilateral but with unequal staining in 5/26 cases and unilateral in 5/26 cases. Expression in the ureter tips was weak or not detected in 4/26 cases.
|
Specimen
4C:
embryonic day 11.0-11.5; Krt25Re/ Krt25Re, Etn2Sd/ Etn2Sd
(more )
Note: The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
Specimen
4C:
(close )
Genetic Background:
|
RSV/LeJ
|
Mutant Allele(s):
|
Krt25Re/Krt25Re Etn2Sd/Etn2Sd
|
Age:
|
embryonic day 11.0-11.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Note:
|
The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: trunk somite |
Present |
Regionally restricted |
4C
|
Expression was partially lost in some mutants and completely lost in others.
|
TS19: tail |
Present |
|
4C
|
|
Specimen
4D:
embryonic day 11.0-11.5; Krt25Re/ Krt25Re, Etn2Sd/ Etn2Sd
(more )
Note: The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
Specimen
4D:
(close )
Genetic Background:
|
RSV/LeJ
|
Mutant Allele(s):
|
Krt25Re/Krt25Re Etn2Sd/Etn2Sd
|
Age:
|
embryonic day 11.0-11.5
|
Sex:
|
Not Specified
|
Type:
|
section from whole mount
|
Note:
|
The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: ureteric bud |
Weak |
Regionally restricted |
4D
|
Expression was detected in the tips bilaterally in 2/13 mutants.
|
Specimen
4E:
embryonic day 11.0-11.5; Krt25Re/ Krt25Re, Etn2Sd/ Etn2Sd
(more )
Note: The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
Specimen
4E:
(close )
Genetic Background:
|
RSV/LeJ
|
Mutant Allele(s):
|
Krt25Re/Krt25Re Etn2Sd/Etn2Sd
|
Age:
|
embryonic day 11.0-11.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Note:
|
The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: trunk somite |
Present |
Regionally restricted |
4E
|
Expression was partially lost in some mutants and completely lost in others.
|
TS19: tail |
Present |
|
4E
|
|
Specimen
4F:
embryonic day 11.0-11.5; Krt25Re/ Krt25Re, Etn2Sd/ Etn2Sd
(more )
Note: The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
Specimen
4F:
(close )
Genetic Background:
|
RSV/LeJ
|
Mutant Allele(s):
|
Krt25Re/Krt25Re Etn2Sd/Etn2Sd
|
Age:
|
embryonic day 11.0-11.5
|
Sex:
|
Not Specified
|
Type:
|
section from whole mount
|
Note:
|
The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: ureteric bud |
Weak |
Regionally restricted |
4F
|
Expression was detected in the tips of an unbranched ureter unilaterally in 3/13 mutants.
|
Specimen
4G:
embryonic day 11.0-11.5; Krt25Re/ Krt25Re, Etn2Sd/ Etn2Sd
(more )
Note: The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
Specimen
4G:
(close )
Genetic Background:
|
RSV/LeJ
|
Mutant Allele(s):
|
Krt25Re/Krt25Re Etn2Sd/Etn2Sd
|
Age:
|
embryonic day 11.0-11.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Note:
|
The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: trunk somite |
Present |
Regionally restricted |
4G
|
Expression was partially lost in some mutants and completely lost in others.
|
TS19: tail |
Present |
|
4G
|
|
Specimen
4H:
embryonic day 11.0-11.5; Krt25Re/ Krt25Re, Etn2Sd/ Etn2Sd
(more )
Note: The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
Specimen
4H:
(close )
Genetic Background:
|
RSV/LeJ
|
Mutant Allele(s):
|
Krt25Re/Krt25Re Etn2Sd/Etn2Sd
|
Age:
|
embryonic day 11.0-11.5
|
Sex:
|
Not Specified
|
Type:
|
section from whole mount
|
Note:
|
The RSV/Le strain is also segregating for varitint waddler (Va). However, the presence (or absence) of the Va allele in this specimen was not noted in the paper.
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: ureteric bud |
Absent |
|
4H
|
The ureter was absent in 8/13 mutants.
|
Specimen
5A:
embryonic day 12.5
(more )
Specimen
5A:
(close )
Genetic Background:
|
Not Specified
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: ureter |
Present |
Regionally restricted |
5A
|
Expression is in the ureter tip.
|
Specimen
5B:
(close )
Genetic Background:
|
involves: 129S1/Sv
|
Mutant Allele(s):
|
Wnt4tm1Amc/Wnt4tm1Amc
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: ureter |
Present |
Regionally restricted |
5B
|
Expression is in the ureter tips as wild type, but the number of branches is decreased in the mutant.
|
Specimen
5C:
embryonic day 14.5
(more )
Specimen
5C:
(close )
Genetic Background:
|
Not Specified
|
Age:
|
embryonic day 14.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS22: ureter |
Present |
Regionally restricted |
5C
|
Expression is in the ureter tip.
|
Specimen
5D:
(close )
Genetic Background:
|
involves: 129S1/Sv
|
Mutant Allele(s):
|
Wnt4tm1Amc/Wnt4tm1Amc
|
Age:
|
embryonic day 14.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Structure |
Level |
Pattern |
Image |
Note |
TS22: ureter |
Present |
Regionally restricted |
5D
|
Expression is in the ureter tip as in wild type but mutants lack the half-moon form indicative of tip branching.
|
|