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Wnt11 Gene Detail
Summary
  • Symbol
    Wnt11
  • Name
    wingless-type MMTV integration site family, member 11
  • Feature Type
    protein coding gene
  • IDs
    MGI:101948
    NCBI Gene: 22411
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:98484293-98503954 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.90 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101948
 protein coding gene Chr7:98484293-98504402 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032543
 protein coding gene Chr7:101593201-101613210 (+)
A/J MGP_AJ_G0032517
 protein coding gene Chr7:99078667-99098666 (+)
AKR/J MGP_AKRJ_G0032453
 protein coding gene Chr7:101432996-101453343 (+)
BALB/cJ MGP_BALBcJ_G0032528
 protein coding gene Chr7:98762486-98782498 (+)
C3H/HeJ MGP_C3HHeJ_G0032243
 protein coding gene Chr7:101779496-101800685 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033026
 protein coding gene Chr7:105514071-105535493 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030021
 protein coding gene Chr7:101504814-101524576 (+)
CAST/EiJ MGP_CASTEiJ_G0031570
 protein coding gene Chr7:93305817-93325926 (+)
CBA/J MGP_CBAJ_G0032210
 protein coding gene Chr7:109102932-109128534 (+)
DBA/2J MGP_DBA2J_G0032362
 protein coding gene Chr7:97405936-97426021 (+)
FVB/NJ MGP_FVBNJ_G0032319
 protein coding gene Chr7:97207057-97227063 (+)
LP/J MGP_LPJ_G0032451
 protein coding gene Chr7:102921121-102941205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032351
 protein coding gene Chr7:110613805-110635120 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033048
 protein coding gene Chr7:100695555-100715589 (+)
PWK/PhJ MGP_PWKPhJ_G0031288
 protein coding gene Chr7:90491857-90512222 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031131
 protein coding gene Chr7:87990249-88010246 (+)
WSB/EiJ MGP_WSBEiJ_G0031687
 protein coding gene Chr7:101366935-101386987 (+)



Homology
more
  • Human Ortholog
    WNT11, Wnt family member 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT11, Wnt family member 11
  • Synonyms
    HWNT11
  • Links
    NCBI Gene ID: 7481
    neXtProt AC: NX_O96014
    UniProt: O96014

  • Chr Location
    11q13.5; chr11:76186325-76210761 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human WNT11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in extensive embryonic lethality and mutants surviving to birth die within the first 2 days of life. The kidneys are small and exhibit delayed development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1731
  • Tissues
    621
  • cDNA Data
    28
  • Literature Summary
    231
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22411 NCBI Gene Model | MGI Sequence Detail 19662 C57BL/6J ±  kb
    transcript NM_001285792 RefSeq | MGI Sequence Detail 3022 ZRU/MplStud  
    polypeptide P48615 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 33
      Primer pair 22
      Other 24

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18782
    References
    more
    • Summaries
      All 303
      Developmental Gene Expression 231
      Gene Ontology 15
      Phenotypes 41
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:343798 Cheng T, et al., Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease. Development. 2023 Dec 15;150(24)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory