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Enpp2 Gene Detail
Summary
  • Symbol
    Enpp2
  • Name
    ectonucleotide pyrophosphatase/phosphodiesterase 2
  • Synonyms
    ATX, Autotaxin, Npps2, PD-Ialpha, Pdnp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321390
    NCBI Gene: 18606
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:54702297-54816284 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 21.60 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2907 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321390
 protein coding gene Chr15:54702297-54816288 (-)
129S1/SvImJ ENSMUSG00200026914
 protein coding gene Chr15:51743628-51745265 (-)
129S1/SvImJ ENSMUSGG00200054774
 protein coding gene Chr15:51756021-51798812 (-)
A/J ENSMUSGG00195055303
 protein coding gene Chr15:51792440-51834797 (-)
A/J ENSMUSG00195005975
 protein coding gene Chr15:51780055-51781696 (-)
AKR/J ENSMUSG00220020615
 protein coding gene Chr15:51787602-51789243 (-)
AKR/J ENSMUSGG00220054816
 protein coding gene Chr15:51799985-51842369 (-)
BALB/cJ ENSMUSG00180008924
 protein coding gene Chr15:51726647-51728284 (-)
BALB/cJ ENSMUSGG00180055029
 protein coding gene Chr15:51739061-51781796 (-)
C3H/HeJ ENSMUSG00175004441
 protein coding gene Chr15:51985214-51986851 (-)
C3H/HeJ ENSMUSGG00175055018
 protein coding gene Chr15:51997632-52040374 (-)
C57BL/6NJ ENSMUSGG00215055587
 protein coding gene Chr15:51736945-51779697 (-)
C57BL/6NJ ENSMUSG00215008478
 protein coding gene Chr15:51724527-51726164 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019793
 protein coding gene Chr15:48999357-49080649 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210007108
 protein coding gene Chr15:51812425-51814062 (-)
CBA/J ENSMUSGG00210055045
 protein coding gene Chr15:51824842-51867569 (-)
DBA/2J ENSMUSGG00185057747
 protein coding gene Chr15:51801035-51843408 (-)
DBA/2J ENSMUSG00185026186
 protein coding gene Chr15:51788651-51790292 (-)
FVB/NJ ENSMUSGG00205054067
 protein coding gene Chr15:51646026-51688413 (-)
FVB/NJ ENSMUSG00205006229
 protein coding gene Chr15:51633642-51635283 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230006065
 protein coding gene Chr15:55105159-55106796 (-)
LP/J ENSMUSGG00230055654
 protein coding gene Chr15:55117548-55160332 (-)
NOD/ShiLtJ ENSMUSG00190016058
 protein coding gene Chr15:51785924-51787561 (-)
NOD/ShiLtJ ENSMUSGG00190054825
 protein coding gene Chr15:51798342-51841064 (-)
NZO/HlLtJ ENSMUSGG00225055672
 protein coding gene Chr15:55444566-55487295 (-)
NZO/HlLtJ ENSMUSG00225028552
 protein coding gene Chr15:55432146-55433783 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010022789
 protein coding gene Chr15:52867939-52948090 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ENPP2, ectonucleotide pyrophosphatase/phosphodiesterase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENPP2, ectonucleotide pyrophosphatase/phosphodiesterase 2
  • Synonyms
    ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2
  • Links
    NCBI Gene ID: 5168
    UniProt: Q13822

  • Chr Location
    8q24.12; chr8:119557085-119673453 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 7 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis, absent yolk sac vasculature, abnormal vasculature, and variable penetrance of impaired embryo turning, edema, failure of chorioallantoic fusion, neural tube malformations, and abnormal forebrain development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1426
  • Tissues
    375
  • cDNA Data
    16
  • Literature Summary
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18606 NCBI Gene Model | MGI Sequence Detail 113988 C57BL/6J ±  kb
    transcript NM_001136077 RefSeq | MGI Sequence Detail 3413 C57BL/6  
    polypeptide Q9R1E6 UniProt | EBI | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 18
      Primer pair 9
      Other 4
      Antibodies 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 42
      Diseases 1
      Gene Ontology 20
      Phenotypes 51
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:391329 Duan CH, et al., Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming. Nat Commun. 2026 Jul 1;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory