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Ap2m1 Gene Detail
Summary
  • Symbol
    Ap2m1
  • Name
    adaptor-related protein complex 2, mu 1 subunit
  • Synonyms
    clathrin-associated AP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298405
    NCBI Gene: 11773
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:20354230-20363659 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 12.46 cM, cytoband 16
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298405
protein coding gene Chr16:20354228-20363659 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022644
protein coding gene Chr16:17873983-17883413 (+)
A/J MGP_AJ_G0022606
protein coding gene Chr16:17010932-17021262 (+)
AKR/J MGP_AKRJ_G0022581
protein coding gene Chr16:17662723-17672837 (+)
BALB/cJ MGP_BALBcJ_G0022610
protein coding gene Chr16:17174221-17183387 (+)
C3H/HeJ MGP_C3HHeJ_G0022375
protein coding gene Chr16:17822726-17831441 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023061
protein coding gene Chr16:18220635-18233017 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020578
protein coding gene Chr16:17701743-17711297 (+)
CAST/EiJ MGP_CASTEiJ_G0021905
protein coding gene Chr16:17797021-17809704 (+)
CBA/J MGP_CBAJ_G0022347
protein coding gene Chr16:18962579-18972610 (+)
DBA/2J MGP_DBA2J_G0022479
protein coding gene Chr16:16940613-16948796 (+)
FVB/NJ MGP_FVBNJ_G0022454
protein coding gene Chr16:16970737-16980164 (+)
LP/J MGP_LPJ_G0022546
protein coding gene Chr16:17604313-17614588 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022474
protein coding gene Chr16:18650606-18665780 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023072
protein coding gene Chr16:17617973-17629184 (+)
PWK/PhJ MGP_PWKPhJ_G0021646
protein coding gene Chr16:17202366-17212464 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021475
protein coding gene Chr16:17422437-17433822 (+)
WSB/EiJ MGP_WSBEiJ_G0021949
protein coding gene Chr16:17609680-17622980 (+)



Homology
more
  • Human Ortholog
    AP2M1, adaptor related protein complex 2 subunit mu 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AP2M1, adaptor related protein complex 2 subunit mu 1
  • Synonyms
    AP50, CLAPM1, MRD60, mu2
  • Links
    NCBI Gene ID: 1173
    neXtProt AC: NX_Q96CW1
    UniProt: Q96CW1

  • Chr Location
    3q27.1; chr3:184174689-184184214 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human AP2M1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted deletion display embryonic lethality before implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11773 NCBI Gene Model | MGI Sequence Detail 9430 C57BL/6J ±  kb
transcript NM_009679 RefSeq | MGI Sequence Detail 2937 C57BL/6  
polypeptide P84091 UniProt | EBI | MGI Sequence Detail 435 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 242
    Genomic 4
    cDNA 234
    Primer pair 1
    Other 3

    Microarray probesets 3
References
more
  • Summaries
    All 53
    Developmental Gene Expression 2
    Gene Ontology 15
    Phenotypes 14
  • Earliest
    J:28934 Ohno H, et al., Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science. 1995 Sep 29;269(5232):1872-5
  • Latest
    J:343451 Camblor-Perujo S, et al., The AP-2 complex interacts with gamma-TuRC and regulates the proliferative capacity of neural progenitors. Life Sci Alliance. 2024 Feb;7(2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory