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Ncaph2 Gene Detail
Summary
  • Symbol
    Ncaph2
  • Name
    non-SMC condensin II complex, subunit H2
  • Synonyms
    0610010J20Rik, 2610524G04Rik, D15Ertd785e, Kleisin beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289164
    NCBI Gene: 52683
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:89239922-89257029 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289164
 protein coding gene Chr15:89239920-89257030 (+)
129S1/SvImJ ENSMUSG00200035202
 protein coding gene Chr15:86392081-86409191 (+)
A/J ENSMUSG00195019536
 protein coding gene Chr15:86313511-86330616 (+)
AKR/J ENSMUSG00220028829
 protein coding gene Chr15:86344086-86361193 (+)
BALB/cJ ENSMUSG00180013841
 protein coding gene Chr15:86167311-86184418 (+)
C3H/HeJ ENSMUSG00175025484
 protein coding gene Chr15:86500112-86517219 (+)
C57BL/6NJ ENSMUSG00215021204
 protein coding gene Chr15:86260856-86277964 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020163
 protein coding gene Chr15:83311029-83327913 (+)
CAST/EiJ ENSTCUG00005029011
 protein coding gene Chr15:85765510-85782615 (+)
CBA/J ENSMUSG00210013003
 protein coding gene Chr15:86269555-86286662 (+)
DBA/2J ENSMUSG00185021867
 protein coding gene Chr15:86281491-86298598 (+)
FVB/NJ ENSMUSG00205023308
 protein coding gene Chr15:86042213-86059321 (+)
JF1/MsJ ENSUMUG00000037965
 protein coding gene Chr15:85848656-85865772 (+)
LP/J ENSMUSG00230042577
 protein coding gene Chr15:89632275-89649384 (+)
NOD/ShiLtJ ENSMUSG00190027064
 protein coding gene Chr15:86285970-86303077 (+)
NZO/HlLtJ ENSMUSG00225049368
 protein coding gene Chr15:89948588-89965695 (+)
PWK/PhJ ENSLUMG00010031368
 protein coding gene Chr15:86001307-86018415 (+)
SPRET/EiJ ENSMSPG00010013589
 protein coding gene Chr15:87703362-87720594 (+)
WSB/EiJ ENSIUOG00005011083
 protein coding gene Chr15:86376243-86393360 (+)



Homology
more
  • Human Ortholog
    NCAPH2, non-SMC condensin II complex subunit H2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCAPH2, non-SMC condensin II complex subunit H2
  • Synonyms
    CAPH2
  • Links
    NCBI Gene ID: 29781
    UniProt: Q6IBW4

  • Chr Location
    22q13.33; chr22:50508213-50524780 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced single point mutation display a specific defect in T cell development but are otherwise viable, fertile and overtly healthy with no apparent defects in B cell development. Homozygous null mice die before E12.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    18
  • cDNA Data
    25
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008690 Ensembl Gene Model | MGI Sequence Detail 17108 C57BL/6J ±  kb
    transcript ENSMUST00000088717 Ensembl | MGI Sequence Detail 3302 Not Applicable  
    polypeptide ENSMUSP00000086095 Ensembl | MGI Sequence Detail 608 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011025 condensin-2 complex subunit H2
      (term hierarchy)
    • InterPro Domains
      IPR031739 Condensin-2 complex subunit H2
      IPR031737 Condensin-2 complex subunit H2, C-terminal
      IPR031719 Condensin II complex subunit H2, middle domain
      IPR009378 Condensin II complex subunit H2, N-terminal
    • GlyGen
      Q8BSP2 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 26
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1914092, MGI:1919756, MGI:2145963
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 12
      Phenotypes 40
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory