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Itgb2l Gene Detail
Summary
  • Symbol
    Itgb2l
  • Name
    integrin beta 2-like
  • Synonyms
    5033406G21Rik, pactolus
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277979
    NCBI Gene: 16415
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:96223488-96244819 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 56.95 cM, cytoband C6
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277979
 protein coding gene Chr16:96223488-96244861 (-)
129S1/SvImJ ENSMUSG00200016510
 protein coding gene Chr16:93158807-93180136 (-)
A/J ENSMUSG00195015315
 protein coding gene Chr16:92917210-92938540 (-)
AKR/J ENSMUSG00220009355
 protein coding gene Chr16:93166543-93187873 (-)
BALB/cJ ENSMUSG00180001231
 protein coding gene Chr16:92991335-93012660 (-)
C3H/HeJ ENSMUSG00175002671
 protein coding gene Chr16:93328079-93349406 (-)
C57BL/6NJ ENSMUSG00215013403
 protein coding gene Chr16:93130502-93151834 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021005
 protein coding gene Chr16:91015780-91037460 (-)
CAST/EiJ ENSTCUG00005012549
 protein coding gene Chr16:92713713-92735070 (-)
CBA/J ENSMUSG00210017821
 protein coding gene Chr16:93229183-93250517 (-)
DBA/2J ENSMUSG00185003435
 protein coding gene Chr16:93175000-93196328 (-)
FVB/NJ ENSMUSG00205015492
 protein coding gene Chr16:92950146-92971480 (-)
JF1/MsJ ENSUMUG00000013301
 protein coding gene Chr16:93291864-93313240 (-)
LP/J ENSMUSG00230028136
 protein coding gene Chr16:95705292-95726623 (-)
NOD/ShiLtJ ENSMUSG00190003600
 protein coding gene Chr16:93137538-93158871 (-)
NZO/HlLtJ ENSMUSG00225030822
 protein coding gene Chr16:98807538-98828871 (-)
PWK/PhJ ENSLUMG00010014560
 protein coding gene Chr16:92942971-92964352 (-)
SPRET/EiJ ENSMSPG00010018911
 protein coding gene Chr16:94059947-94080856 (-)
WSB/EiJ ENSIUOG00005013549
 protein coding gene Chr16:93081002-93102355 (-)



Homology
more
  • Human Ortholog
    ITGB2, integrin subunit beta 2
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB2, integrin subunit beta 2
  • Synonyms
    CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
  • Links
    NCBI Gene ID: 3689
    UniProt: P05107

  • Chr Location
    21q22.3; chr21:44885948-44932079 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human ITGB2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    98 phenotype references
Mice homozygous for a null allele display normal leukocyte development and normal neutrophil recruitment to inflamed tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000157 Ensembl Gene Model | MGI Sequence Detail 21332 C57BL/6J ±  kb
transcript ENSMUST00000113773 Ensembl | MGI Sequence Detail 2806 Not Applicable  
polypeptide ENSMUSP00000109403 Ensembl | MGI Sequence Detail 795 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 4
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
less
MGI:1923228
References
more
  • Summaries
    All 125
    Diseases 6
    Gene Ontology 7
    Phenotypes 98
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory