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Sp3 Gene Detail
Summary
  • Symbol
    Sp3
  • Name
    trans-acting transcription factor 3
  • Synonyms
    D130027J01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277166
    NCBI Gene: 20687
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:72766774-72810790 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 43.35 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    819 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277166
 protein coding gene Chr2:72766771-72810790 (-)
129S1/SvImJ ENSMUSG00200035902
 protein coding gene Chr2:69835393-69879418 (-)
A/J ENSMUSG00195022406
 protein coding gene Chr2:69981967-70025985 (-)
AKR/J ENSMUSG00220039419
 protein coding gene Chr2:69946569-69990586 (-)
BALB/cJ ENSMUSG00180037066
 protein coding gene Chr2:69935738-69979769 (-)
C3H/HeJ ENSMUSG00175033337
 protein coding gene Chr2:70050719-70094741 (-)
C57BL/6NJ ENSMUSG00215016251
 protein coding gene Chr2:69877980-69921997 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023653
 protein coding gene Chr2:67507796-67554820 (-)
CAST/EiJ ENSTCUG00005008943
 protein coding gene Chr2:69359693-69403799 (-)
CBA/J ENSMUSG00210033193
 protein coding gene Chr2:70093499-70137519 (-)
DBA/2J ENSMUSG00185038782
 protein coding gene Chr2:69929253-69973274 (-)
FVB/NJ ENSMUSG00205026482
 protein coding gene Chr2:69392019-69436040 (-)
JF1/MsJ ENSUMUG00000005694
 protein coding gene Chr2:69580973-69624886 (-)
LP/J ENSMUSG00230020981
 protein coding gene Chr2:71735127-71779148 (-)
NOD/ShiLtJ ENSMUSG00190038571
 protein coding gene Chr2:70014753-70058771 (-)
NZO/HlLtJ ENSMUSG00225014075
 protein coding gene Chr2:79478610-79522631 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010031861
 protein coding gene Chr2:71240876-71285931 (-)
WSB/EiJ ENSIUOG00005018783
 protein coding gene Chr2:70058690-70101432 (-)



Homology
more
  • Human Ortholog
    SP3, Sp3 transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SP3, Sp3 transcription factor
  • Synonyms
    SPR2
  • Links
    NCBI Gene ID: 6670
    UniProt: Q02447

  • Chr Location
    2q31.1; chr2:173880850-173965702 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 2 alleles in 1 genetic background
    25 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a reduced birth body size, skeletal, tooth and hematopoietic defects, and die shortly after birth due to respiratory failure. Homozygous mutant mice bearing a subtle point mutation in the SUMO attachment site show loss of DNAmethylation in sumoylation-deficient MEFs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    690
  • Tissues
    81
  • cDNA Data
    22
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20687 NCBI Gene Model | MGI Sequence Detail 44017 C57BL/6J ±  kb
    transcript NM_001018042 RefSeq | MGI Sequence Detail 4191 C57BL/6  
    polypeptide O70494 UniProt | EBI | MGI Sequence Detail 783 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 22
      Primer pair 3
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2444244
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 17
      Gene Ontology 19
      Phenotypes 40
    • Earliest
      J:38986 Madsen CS, et al., Expression of the smooth muscle myosin heavy chain gene is regulated by a negative-acting GC-rich element located between two positive-acting serum response factor-binding elements. J Biol Chem. 1997 Mar 7;272(10):6332-40
    • Latest
      J:381085 Kabir M, et al., A machine learning classifier to identify and prioritise genes associated with murine cardiac development. PLoS Genet. 2026 Feb;22(2):e1011489
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory