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Ptp4a2 Gene Detail
Summary
  • Symbol
    Ptp4a2
  • Name
    protein tyrosine phosphatase 4a2
  • Synonyms
    Prl-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277117
    NCBI Gene: 19244
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129714262-129743796 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 63.38 cM, cytoband D2.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    185 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277117
 protein coding gene Chr4:129705012-129743796 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028839
 protein coding gene Chr4:131775336-131823960 (+)
A/J MGP_AJ_G0028798
 protein coding gene Chr4:126498176-126536149 (+)
AKR/J MGP_AKRJ_G0028751
 protein coding gene Chr4:130022605-130062227 (+)
BALB/cJ MGP_BALBcJ_G0028821
 protein coding gene Chr4:127096485-127134171 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0029263
 protein coding gene Chr4:136722973-136763374 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026535
 protein coding gene Chr4:119622186-119658484 (+)
CAST/EiJ MGP_CASTEiJ_G0027967
 protein coding gene Chr4:128269462-128312457 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0028617
 protein coding gene Chr4:125685124-125737342 (+)
LP/J MGP_LPJ_G0028751
 protein coding gene Chr4:132075227-132117853 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028643
 protein coding gene Chr4:144913106-144954000 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029301
 protein coding gene Chr4:130392312-130442049 (+)
PWK/PhJ MGP_PWKPhJ_G0027689
 protein coding gene Chr4:123535243-123574562 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027515
 protein coding gene Chr4:126278966-126319976 (+)
WSB/EiJ MGP_WSBEiJ_G0028048
 protein coding gene Chr4:130527604-130569635 (+)



Homology
more
  • Human Ortholog
    PTP4A2, protein tyrosine phosphatase 4A2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTP4A2, protein tyrosine phosphatase 4A2
  • Synonyms
    HH13, HH7-2, HU-PP-1, OV-1, PRL2, PRL-2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b
  • Links
    NCBI Gene ID: 8073
    neXtProt AC: NX_Q12974
    UniProt: Q12974

  • Chr Location
    1p35.2; chr1:31906421-31944856 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    3 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit growth retardation associated with reduced decidual, spongiotrophoblast (due to reduced cell proliferation) and placental labyrinth. Male mice show atrophied testis and low sperm count, leading to impaired reproductive ability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    21
  • cDNA Data
    18
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19244 NCBI Gene Model | MGI Sequence Detail 29535 C57BL/6J ±  kb
    transcript NM_001424824 RefSeq | MGI Sequence Detail 3765 C57BL/6  
    polypeptide O70274 UniProt | EBI | MGI Sequence Detail 167 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 28
    • Earliest
      J:46627 Zeng Q, et al., Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun. 1998 Mar 17;244(2):421-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/30/2024
    MGI 6.23     		The Jackson Laboratory