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Birc6 Gene Detail
Summary
  • Symbol
    Birc6
  • Name
    baculoviral IAP repeat-containing 6
  • Synonyms
    A430032G04Rik, A430040A19Rik, apollon, Bruce, D630005A10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276108
    NCBI Gene: 12211
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:74835290-75010351 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 45.64 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    623 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276108
protein coding gene Chr17:74835247-75010351 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024031
protein coding gene Chr17:77188969-77380698 (+)
A/J MGP_AJ_G0023988
protein coding gene Chr17:74816304-74993622 (+)
AKR/J MGP_AKRJ_G0023957
protein coding gene Chr17:75891146-76081684 (+)
BALB/cJ MGP_BALBcJ_G0023990
protein coding gene Chr17:74712032-74889413 (+)
C3H/HeJ MGP_C3HHeJ_G0023754
protein coding gene Chr17:76810774-76992730 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024435
protein coding gene Chr17:79951941-80151638 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021879
protein coding gene Chr17:70439574-70614074 (+)
CAST/EiJ MGP_CASTEiJ_G0023234
protein coding gene Chr17:77334237-77523995 (+)
CBA/J MGP_CBAJ_G0023728
protein coding gene Chr17:83310270-83511302 (+)
DBA/2J MGP_DBA2J_G0023857
protein coding gene Chr17:73395552-73572187 (+)
FVB/NJ MGP_FVBNJ_G0023823
protein coding gene Chr17:72898922-73083012 (+)
LP/J MGP_LPJ_G0023940
protein coding gene Chr17:77945024-78149263 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023851
protein coding gene Chr17:83117367-83308564 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024479
protein coding gene Chr17:76366415-76545983 (+)
PWK/PhJ MGP_PWKPhJ_G0022980
protein coding gene Chr17:72778038-72959675 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022791
protein coding gene Chr17:73077106-73272195 (+)
WSB/EiJ MGP_WSBEiJ_G0023301
protein coding gene Chr17:77229167-77418964 (+)



Homology
more
  • Human Ortholog
    BIRC6, baculoviral IAP repeat containing 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BIRC6, baculoviral IAP repeat containing 6
  • Synonyms
    APOLLON, BRUCE
  • Links
    NCBI Gene ID: 57448
    neXtProt AC: NX_Q9NR09
    UniProt: Q9NR09

  • Chr Location
    2p22.3; chr2:32357023-32619571 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 7 alleles in 6 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit perinatal lethality and exhibit placental defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024073 Ensembl Gene Model | MGI Sequence Detail 175062 C57BL/6J ±  kb
    transcript ENSMUST00000182597 Ensembl | MGI Sequence Detail 14649 Not Applicable  
    polypeptide ENSMUSP00000138333 Ensembl | MGI Sequence Detail 4882 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 33

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2442816, MGI:2444799, MGI:2444861, MGI:3034286
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:48143 Hauser HP, et al., A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors. J Cell Biol. 1998 Jun 15;141(6):1415-22
    • Latest
      J:220313 Ge C, et al., BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1210-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory