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Cidea Gene Detail
Summary
  • Symbol
    Cidea
  • Name
    cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270845
    NCBI Gene: 12683
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:67476674-67500855 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 39.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270845
 protein coding gene Chr18:67476634-67500864 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024522
 protein coding gene Chr18:67621848-67652064 (+)
A/J MGP_AJ_G0024489
 protein coding gene Chr18:64672326-64697713 (+)
AKR/J MGP_AKRJ_G0024459
 protein coding gene Chr18:66571713-66597517 (+)
BALB/cJ MGP_BALBcJ_G0024488
 protein coding gene Chr18:64839034-64864898 (+)
C3H/HeJ MGP_C3HHeJ_G0024256
 protein coding gene Chr18:66723506-66749728 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024935
 protein coding gene Chr18:69419912-69444732 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022366
 protein coding gene Chr18:64048832-64073537 (+)
CAST/EiJ MGP_CASTEiJ_G0023729
 protein coding gene Chr18:66722623-66751125 (+)
CBA/J MGP_CBAJ_G0024226
 protein coding gene Chr18:71799858-71833214 (+)
DBA/2J MGP_DBA2J_G0024356
 protein coding gene Chr18:64323579-64349743 (+)
FVB/NJ MGP_FVBNJ_G0024322
 protein coding gene Chr18:63696605-63724004 (+)
LP/J MGP_LPJ_G0024440
 protein coding gene Chr18:67483240-67520668 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024351
 protein coding gene Chr18:73079810-73104621 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024982
 protein coding gene Chr18:66733382-66761854 (+)
PWK/PhJ MGP_PWKPhJ_G0023472
 protein coding gene Chr18:64599697-64629060 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023277
 protein coding gene Chr18:66897465-66920604 (+)
WSB/EiJ MGP_WSBEiJ_G0023793
 protein coding gene Chr18:66629783-66666370 (+)



Homology
more
  • Human Ortholog
    CIDEA, cell death inducing DFFA like effector a
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIDEA, cell death inducing DFFA like effector a
  • Synonyms
    CIDE-A
  • Links
    NCBI Gene ID: 1149
    neXtProt AC: NX_O60543
    UniProt: O60543

  • Chr Location
    18p11.21; chr18:12254361-12277595 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CIDEA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show higher metabolic rate, lipolysis in BAT and core body temperature when subjected to cold treatment. They are lean and resistant to diet-induced obesity. Aging homozygotes exhibit dry eyes and hair, reduced sebaceous lipid secretion, hair loss, and poor water repulsion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    8
  • cDNA Data
    60
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024526 Ensembl Gene Model | MGI Sequence Detail 24182 C57BL/6J ±  kb
    transcript ENSMUST00000025404 Ensembl | MGI Sequence Detail 1115 Not Applicable  
    polypeptide ENSMUSP00000025404 Ensembl | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 60
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147356
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 32
      Gene Ontology 17
      Phenotypes 15
    • Earliest
      J:47647 Inohara N, et al., CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998 May 1;17(9):2526-33
    • Latest
      J:337469 Park A, et al., Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice. Nat Commun. 2023 Jun 23;14(1):3746
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory