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Map6 Gene Detail
Summary
  • Symbol
    Map6
  • Name
    microtubule-associated protein 6
  • Synonyms
    2810411E12Rik, F-STOP, Mtap6, STOP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201690
    NCBI Gene: 17760
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:98916654-98986344 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.05 cM, cytoband E2-F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    851 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201690
protein coding gene Chr7:98916270-98986344 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032547
protein coding gene Chr7:102053491-102127385 (+)
A/J MGP_AJ_G0032521
protein coding gene Chr7:99517373-99584749 (+)
AKR/J MGP_AKRJ_G0032457
protein coding gene Chr7:101875312-101946856 (+)
BALB/cJ MGP_BALBcJ_G0032532
protein coding gene Chr7:99202142-99268894 (+)
C3H/HeJ MGP_C3HHeJ_G0032247
protein coding gene Chr7:102241717-102308945 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033030
protein coding gene Chr7:105968220-106040467 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030025
protein coding gene Chr7:101948262-102014133 (+)
CAST/EiJ MGP_CASTEiJ_G0031574
protein coding gene Chr7:93779178-93849229 (+)
CBA/J MGP_CBAJ_G0032214
protein coding gene Chr7:109598483-109676893 (+)
DBA/2J MGP_DBA2J_G0032366
protein coding gene Chr7:97856374-97924469 (+)
FVB/NJ MGP_FVBNJ_G0032323
protein coding gene Chr7:97645499-97712416 (+)
LP/J MGP_LPJ_G0032455
protein coding gene Chr7:103380256-103450359 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032355
protein coding gene Chr7:111069195-111138058 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033052
protein coding gene Chr7:101154058-101223951 (+)
PWK/PhJ MGP_PWKPhJ_G0031292
protein coding gene Chr7:90947663-91015854 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031135
protein coding gene Chr7:88455452-88525390 (+)
WSB/EiJ MGP_WSBEiJ_G0031691
protein coding gene Chr7:101815606-101888787 (+)



Homology
more
  • Human Ortholog
    MAP6, microtubule associated protein 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP6, microtubule associated protein 6
  • Synonyms
    MAP6-N, MTAP6, N-STOP, STOP
  • Links
    NCBI Gene ID: 4135
    neXtProt AC: NX_Q96JE9
    UniProt: Q96JE9

  • Chr Location
    11q13.5; chr11:75586918-75669038 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Map6 mouse models

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Map6
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Mice homozygous for a targeted null mutation are devoid of cold-stable microtubules, and exhibit impaired synaptic plasticity, associated with severe behavioral abnormalities that are specifically ameliorated by long-term administration of neuroleptics.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055407 Ensembl Gene Model | MGI Sequence Detail 69691 C57BL/6J ±  kb
transcript ENSMUST00000207883 Ensembl | MGI Sequence Detail 3431 Not Applicable  
polypeptide ENSMUSP00000146585 Ensembl | MGI Sequence Detail 906 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 4
    cDNA 13

    Microarray probesets 4
Other
Accession IDs
less
MGI:2152340
References
more
  • Summaries
    All 69
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 6
    Phenotypes 34
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:316779 Boulan B, et al., CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway. Elife. 2021 Dec 3;10:e70361

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory