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Rhpn1 Gene Detail
Summary
  • Symbol
    Rhpn1
  • Name
    rhophilin, Rho GTPase binding protein 1
  • Synonyms
    Grbp, Rhophilin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098783
    NCBI Gene: 14787
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:75576097-75586268 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.76 cM, cytoband E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098783
 protein coding gene Chr15:75576097-75587334 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021957
 protein coding gene Chr15:75731290-75741415 (+)
A/J MGP_AJ_G0021915
 protein coding gene Chr15:72986031-72996161 (+)
AKR/J MGP_AKRJ_G0021898
 protein coding gene Chr15:74950325-74960455 (+)
BALB/cJ MGP_BALBcJ_G0021924
 protein coding gene Chr15:72998466-73008591 (+)
C3H/HeJ MGP_C3HHeJ_G0021696
 protein coding gene Chr15:75014531-75024665 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022364
 protein coding gene Chr15:78565397-78575527 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019895
 protein coding gene Chr15:69662357-69672408 (+)
CAST/EiJ MGP_CASTEiJ_G0021215
 protein coding gene Chr15:75796827-75806944 (+)
CBA/J MGP_CBAJ_G0021663
 protein coding gene Chr15:81092543-81102673 (+)
DBA/2J MGP_DBA2J_G0021788
 protein coding gene Chr15:72500271-72510376 (+)
FVB/NJ MGP_FVBNJ_G0021769
 protein coding gene Chr15:71558965-71570933 (+)
LP/J MGP_LPJ_G0021859
 protein coding gene Chr15:75824988-75835118 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021793
 protein coding gene Chr15:86377706-86387812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022384
 protein coding gene Chr15:75200513-75210615 (+)
PWK/PhJ MGP_PWKPhJ_G0020956
 protein coding gene Chr15:72640913-72651055 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020795
 protein coding gene Chr15:74933924-74943947 (+)
WSB/EiJ MGP_WSBEiJ_G0021267
 protein coding gene Chr15:75286781-75296892 (+)



Homology
more
  • Human Ortholog
    RHPN1, rhophilin Rho GTPase binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHPN1, rhophilin Rho GTPase binding protein 1
  • Synonyms
    ODF5, RHOPHILIN, RHPN
  • Links
    NCBI Gene ID: 114822
    neXtProt AC: NX_Q8TCX5
    UniProt: Q8TCX5

  • Chr Location
    8q24.3; chr8:143364255-143384221 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are albuminuric, show podocyte foot process effacement, thickening of the glomerular basement membrane, and focal segmental glomerulosclerosis lesions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    99
  • cDNA Data
    17
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14787 NCBI Gene Model | MGI Sequence Detail 10172 C57BL/6J ±  kb
    transcript NM_001411251 RefSeq | MGI Sequence Detail 2258 C57BL/6  
    polypeptide Q61085 UniProt | EBI | MGI Sequence Detail 643 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146254
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 4
      Phenotypes 31
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:288722 Nilsson D, et al., Foxc2 is essential for podocyte function. Physiol Rep. 2019 May;7(9):e14083
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory