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Rgs2 Gene Detail
Summary
  • Symbol
    Rgs2
  • Name
    regulator of G-protein signaling 2
  • Synonyms
    GOS8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098271
    NCBI Gene: 19735
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:143875076-143879887 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.56 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098271
 protein coding gene Chr1:143875076-143879899 (-)
129S1/SvImJ ENSMUSG00200007697
 protein coding gene Chr1:141349419-141354230 (-)
A/J ENSMUSG00195016187
 protein coding gene Chr1:140657507-140662302 (-)
AKR/J ENSMUSG00220002618
 protein coding gene Chr1:140428125-140432920 (-)
BALB/cJ ENSMUSG00180011260
 protein coding gene Chr1:140879437-140884260 (-)
C3H/HeJ ENSMUSG00175006616
 protein coding gene Chr1:140856832-140861627 (-)
C57BL/6NJ ENSMUSG00215013900
 protein coding gene Chr1:140808807-140813630 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014678
 protein coding gene Chr1:135230663-135235452 (-)
CAST/EiJ ENSTCUG00005013232
 protein coding gene Chr1:139624122-139628952 (-)
CBA/J ENSMUSG00210014258
 protein coding gene Chr1:140818849-140823644 (-)
DBA/2J ENSMUSG00185006922
 protein coding gene Chr1:145128043-145132868 (-)
FVB/NJ ENSMUSG00205002086
 protein coding gene Chr1:140040815-140045610 (-)
JF1/MsJ ENSUMUG00000011306
 protein coding gene Chr1:144430937-144435738 (-)
LP/J ENSMUSG00230000377
 protein coding gene Chr1:144641503-144646322 (-)
NOD/ShiLtJ ENSMUSG00190002177
 protein coding gene Chr1:140640124-140644946 (-)
NZO/HlLtJ ENSMUSG00225000080
 protein coding gene Chr1:148408067-148412878 (-)
PWK/PhJ ENSLUMG00010001700
 protein coding gene Chr1:139749802-139754595 (-)
SPRET/EiJ ENSMSPG00010011996
 protein coding gene Chr1:142654419-142659239 (-)
WSB/EiJ ENSIUOG00005025598
 protein coding gene Chr1:140178612-140183451 (-)



Homology
more
  • Human Ortholog
    RGS2, regulator of G protein signaling 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS2, regulator of G protein signaling 2
  • Synonyms
    G0S8
  • Links
    NCBI Gene ID: 5997
    UniProt: P41220

  • Chr Location
    1q31.2; chr1:192809039-192812275 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 6 genetic backgrounds
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygous and homozygous mice for one allele display equivalent levels of blood pressure elevation, renovascular defects, persistent constriction of the resistance vasculature, and prolonged response of the vasculature to vasoconstrictors in vivo. Mice homozygous for another allele appear normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    99
  • cDNA Data
    14
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19735 NCBI Gene Model | MGI Sequence Detail 4812 C57BL/6J ±  kb
    transcript NM_009061 RefSeq | MGI Sequence Detail 3009 C57BL/6  
    polypeptide O08849 UniProt | EBI | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 14
      Primer pair 3
      Other 1
      Antibodies 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 10
      Gene Ontology 16
      Phenotypes 65
    • Earliest
      J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
    • Latest
      J:368667 Joshi JC, et al., RGS2 is an innate immune checkpoint for suppressing Galphaq-mediated IFNgamma generation and lung injury. iScience. 2025 Feb 21;28(2):111878
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory