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Khk Gene Detail
Summary
  • Symbol
    Khk
  • Name
    ketohexokinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096353
    NCBI Gene: 16548
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31078780-31088592 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 16.90 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    358 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096353
 protein coding gene Chr5:31078775-31088592 (+)
129S1/SvImJ ENSMUSG00200013650
 protein coding gene Chr5:26580921-26590739 (+)
A/J ENSMUSG00195043165
 protein coding gene Chr5:26027104-26036924 (+)
AKR/J ENSMUSG00220008850
 protein coding gene Chr5:26042107-26051930 (+)
BALB/cJ ENSMUSG00180029514
 protein coding gene Chr5:25831695-25841515 (+)
C3H/HeJ ENSMUSG00175042372
 protein coding gene Chr5:27806036-27815855 (+)
C57BL/6NJ ENSMUSG00215036960
 protein coding gene Chr5:26541688-26551506 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027069
 protein coding gene Chr5:25420916-25431282 (+)
CAST/EiJ ENSTCUG00005019844
 protein coding gene Chr5:26007458-26017250 (+)
CBA/J ENSMUSG00210044667
 protein coding gene Chr5:26779196-26789015 (+)
DBA/2J ENSMUSG00185037709
 protein coding gene Chr5:28632945-28642763 (+)
FVB/NJ ENSMUSG00205034430
 protein coding gene Chr5:25530608-25540428 (+)
JF1/MsJ ENSUMUG00000048369
 protein coding gene Chr5:33173441-33183259 (+)
LP/J ENSMUSG00230047165
 protein coding gene Chr5:33251353-33261171 (+)
NOD/ShiLtJ ENSMUSG00190014171
 protein coding gene Chr5:25829981-25839800 (+)
NZO/HlLtJ ENSMUSG00225016236
 protein coding gene Chr5:38457486-38467304 (+)
PWK/PhJ ENSLUMG00010044786
 protein coding gene Chr5:25923997-25933812 (+)
SPRET/EiJ ENSMSPG00010039365
 protein coding gene Chr5:27092287-27102032 (+)
WSB/EiJ ENSIUOG00005040062
 protein coding gene Chr5:28723038-28732856 (+)



Homology
more
  • Human Ortholog
    KHK, ketohexokinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KHK, ketohexokinase
  • Synonyms
    FRUCTU
  • Links
    NCBI Gene ID: 3795
    UniProt: P50053

  • Chr Location
    2p23.3; chr2:27086723-27100777 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KHK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from multigenic genotypes
    62 phenotype references
  • All Mutations and Alleles
    26
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    10
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    10
  • Genomic Mutations
    5 involving Khk
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    26 strains or lines available
Mice homozygous for alleles that do not produce isoform A or isoforms A and C exhibit normal fertility, development, blood chemistry, and tissue metabolite levels. However, fructose-induced metabolic syndrome is exacerbated in mice lacking only isoform A and is prevented in mice lacking both isoform A and C.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    124
  • cDNA Data
    144
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16548 NCBI Gene Model | MGI Sequence Detail 9813 C57BL/6J ±  kb
transcript NM_001310524 RefSeq | MGI Sequence Detail 1590 ZRU/MplStud  
polypeptide P97328 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 147
    cDNA 145
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 101
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 22
    Phenotypes 62
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:381868 Pham B, et al., Mechanical Compression Causes Lung Hypoplasia in Congenital Diaphragmatic Hernia with GATA4 Genetic Variants. Am J Physiol Lung Cell Mol Physiol. 2026 Mar 5;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory