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Spin1 Gene Detail
Summary
  • Symbol
    Spin1
  • Name
    spindlin 1
  • Synonyms
    Spin
  • Feature Type
    protein coding gene
  • IDs
    MGI:109242
    NCBI Gene: 20729
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:51254916-51306582 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 26.04 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109242
 protein coding gene Chr13:51254523-51306588 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020547
 protein coding gene Chr13:50279173-50329545 (+)
A/J MGP_AJ_G0020501
 protein coding gene Chr13:48514483-48566572 (+)
AKR/J MGP_AKRJ_G0020479
 protein coding gene Chr13:49892895-49950040 (+)
BALB/cJ MGP_BALBcJ_G0020497
 protein coding gene Chr13:48683930-48758107 (+)
C3H/HeJ MGP_C3HHeJ_G0020297
 protein coding gene Chr13:49721286-49773933 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020931
 protein coding gene Chr13:51843082-51896615 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018513
 protein coding gene Chr13:46311134-46359992 (+)
CAST/EiJ MGP_CASTEiJ_G0019810
 protein coding gene Chr13:49675281-49728973 (+)
CBA/J MGP_CBAJ_G0020256
 protein coding gene Chr13:53862296-53915223 (+)
DBA/2J MGP_DBA2J_G0020379
 protein coding gene Chr13:48067997-48124754 (+)
FVB/NJ MGP_FVBNJ_G0020358
 protein coding gene Chr13:47501488-47557062 (+)
LP/J MGP_LPJ_G0020455
 protein coding gene Chr13:50553142-50607499 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020387
 protein coding gene Chr13:53470023-53520150 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020974
 protein coding gene Chr13:49448564-49505115 (+)
PWK/PhJ MGP_PWKPhJ_G0019567
 protein coding gene Chr13:48000805-48054251 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019394
 protein coding gene Chr13:48352430-48400211 (+)
WSB/EiJ MGP_WSBEiJ_G0019872
 protein coding gene Chr13:49752672-49808072 (+)



Homology
more
  • Human Ortholog
    SPIN1, spindlin 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPIN1, spindlin 1
  • Synonyms
    SPIN, TDRD24
  • Links
    NCBI Gene ID: 10927
    neXtProt AC: NX_Q9Y657
    UniProt: Q9Y657

  • Chr Location
    9q22.1; chr9:88388430-88478694 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele display complete postnatal lethality. Although mutant female mice exhibit normal follicular development and oocyte growth, fully grown oocytes are defective in resuming meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    51
  • cDNA Data
    339
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021395 Ensembl Gene Model | MGI Sequence Detail 51667 C57BL/6J ±  kb
    transcript ENSMUST00000095797 Ensembl | MGI Sequence Detail 4434 Not Applicable  
    polypeptide ENSMUSP00000093473 Ensembl | MGI Sequence Detail 262 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 342
      cDNA 339
      Primer pair 3

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-38287, MGI:2142957, MGI:2145170
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory