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Kif21a Gene Detail
Summary
  • Symbol
    Kif21a
  • Name
    kinesin family member 21A
  • Synonyms
    mKIAA1708, N-5 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:109188
    NCBI Gene: 16564
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:90817479-90934151 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 45.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4363 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109188
 protein coding gene Chr15:90817478-90934547 (-)
129S1/SvImJ ENSMUSG00200034897
 protein coding gene Chr15:87995468-88113149 (-)
A/J ENSMUSG00195018151
 protein coding gene Chr15:87891380-88006895 (-)
AKR/J ENSMUSG00220026298
 protein coding gene Chr15:87913362-88030904 (-)
BALB/cJ ENSMUSG00180014086
 protein coding gene Chr15:87743259-87860790 (-)
C3H/HeJ ENSMUSG00175023886
 protein coding gene Chr15:88077827-88193346 (-)
C57BL/6NJ ENSMUSG00215022051
 protein coding gene Chr15:87853890-87971428 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020181
 protein coding gene Chr15:84808524-84925116 (-)
CAST/EiJ ENSTCUG00005030230
 protein coding gene Chr15:87346642-87463732 (-)
CBA/J ENSMUSG00210013074
 protein coding gene Chr15:87847253-87962793 (-)
DBA/2J ENSMUSG00185020817
 protein coding gene Chr15:87861154-87978818 (-)
FVB/NJ ENSMUSG00205028418
 protein coding gene Chr15:87619659-87735179 (-)
JF1/MsJ ENSUMUG00000016353
 protein coding gene Chr15:87401767-87518881 (-)
LP/J ENSMUSG00230044106
 protein coding gene Chr15:91217841-91335515 (-)
NOD/ShiLtJ ENSMUSG00190025118
 protein coding gene Chr15:87892453-88007969 (-)
NZO/HlLtJ ENSMUSG00225042673
 protein coding gene Chr15:91534479-91649976 (-)
PWK/PhJ ENSLUMG00010033067
 protein coding gene Chr15:87557554-87674577 (-)
SPRET/EiJ ENSMSPG00010013040
 protein coding gene Chr15:89323527-89439453 (-)
WSB/EiJ ENSIUOG00005010313
 protein coding gene Chr15:87947979-88065242 (-)



Homology
more
  • Human Ortholog
    KIF21A, kinesin family member 21A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF21A, kinesin family member 21A
  • Synonyms
    CFEOM1, FEOM1, FEOM3A
  • Links
    NCBI Gene ID: 55605
    UniProt: Q7Z4S6

  • Chr Location
    12q12; chr12:39293228-39443718 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kif21a mouse models; 1 with human KIF21A associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice die neonatally with no apparent oculomotor nerve pathology. Mice harboring a humanized amino acid substitution show uni- or bilateral ptosis, globe retraction, reduced numbers of oculomotor nerve and abducens motor neurons, and altered extraocular muscle morphology and innervation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    81
  • cDNA Data
    120
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022629 Ensembl Gene Model | MGI Sequence Detail 116673 C57BL/6J ±  kb
    transcript ENSMUST00000088614 Ensembl | MGI Sequence Detail 6333 Not Applicable  
    polypeptide ENSMUSP00000085985 Ensembl | MGI Sequence Detail 1672 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      cDNA 120
      Primer pair 1
      Other 1
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-38232, MGI:2146087
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 8
      Phenotypes 30
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory