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Fzd3 Gene Detail
Summary
  • Symbol
    Fzd3
  • Name
    frizzled class receptor 3
  • Synonyms
    D930050A07Rik, Fz3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108476
    NCBI Gene: 14365
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:65429898-65499912 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.09 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1536 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108476
 protein coding gene Chr14:65429890-65499912 (-)
129S1/SvImJ ENSMUSG00200028640
 protein coding gene Chr14:54035335-54105375 (-)
A/J ENSMUSG00195014249
 protein coding gene Chr14:54212847-54282887 (-)
AKR/J ENSMUSG00220030305
 protein coding gene Chr14:53553362-53623400 (-)
BALB/cJ ENSMUSG00180034452
 protein coding gene Chr14:53829025-53899075 (-)
C3H/HeJ ENSMUSG00175037063
 protein coding gene Chr14:55571716-55641762 (-)
C57BL/6NJ ENSMUSG00215019775
 protein coding gene Chr14:53762723-53832739 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019421
 protein coding gene Chr14:56346158-56409551 (-)
CAST/EiJ ENSTCUG00005037962
 protein coding gene Chr14:55466857-55536392 (-)
CBA/J ENSMUSG00210035047
 protein coding gene Chr14:54200216-54270264 (-)
DBA/2J ENSMUSG00185028965
 protein coding gene Chr14:59369542-59439588 (-)
FVB/NJ ENSMUSG00205035915
 protein coding gene Chr14:53715690-53785727 (-)
JF1/MsJ ENSUMUG00000024713
 protein coding gene Chr14:70535292-70604919 (-)
LP/J ENSMUSG00230036249
 protein coding gene Chr14:71398878-71468920 (-)
NOD/ShiLtJ ENSMUSG00190033423
 protein coding gene Chr14:53994938-54064973 (-)
NZO/HlLtJ ENSMUSG00225039414
 protein coding gene Chr14:61727910-61797946 (-)
PWK/PhJ ENSLUMG00010035921
 protein coding gene Chr14:53422779-53492687 (-)
SPRET/EiJ ENSMSPG00010027452
 protein coding gene Chr14:56917464-56974248 (-)
WSB/EiJ ENSIUOG00005037434
 protein coding gene Chr14:53430193-53500253 (-)



Homology
more
  • Human Ortholog
    FZD3, frizzled class receptor 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FZD3, frizzled class receptor 3
  • Synonyms
    Fz-3
  • Links
    NCBI Gene ID: 7976
    UniProt: Q9NPG1

  • Chr Location
    8p21.1; chr8:28494205-28574267 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human FZD3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene die within 30 minutes of birth. Breathing is irregular. Brain development is abnormal with occasion falure of the cephalic neural tube to close.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1156
  • Tissues
    396
  • cDNA Data
    22
  • Literature Summary
    107
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007989 Ensembl Gene Model | MGI Sequence Detail 70015 C57BL/6J ±  kb
    transcript ENSMUST00000131309 Ensembl | MGI Sequence Detail 12734 Not Applicable  
    polypeptide ENSMUSP00000115325 Ensembl | MGI Sequence Detail 666 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 1
      cDNA 23
      Primer pair 21
      Other 7
      Antibodies 7

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-37520, MGI:2145736, MGI:2445148
    References
    more
    • Summaries
      All 170
      Developmental Gene Expression 107
      Diseases 1
      Gene Ontology 24
      Phenotypes 39
    • Earliest
      J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
    • Latest
      J:385828 Jarysta A, et al., Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling. Development. 2026 May 1;153(9):dev205332
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory