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Rock1 Gene Detail
Summary
  • Symbol
    Rock1
  • Name
    Rho-associated coiled-coil containing protein kinase 1
  • Synonyms
    1110055K06Rik, Rock-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:107927
    NCBI Gene: 19877
  • Alliance
    genome feature page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:10064401-10182045 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 4.91 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2145 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107927
 protein coding gene Chr18:10064401-10182225 (-)
129S1/SvImJ ENSMUSG00200024150
 protein coding gene Chr18:7013636-7136485 (-)
A/J ENSMUSG00195008450
 protein coding gene Chr18:7176643-7294265 (-)
AKR/J ENSMUSG00220018578
 protein coding gene Chr18:7167830-7285453 (-)
BALB/cJ ENSMUSG00180005307
 protein coding gene Chr18:7623812-7741447 (-)
C3H/HeJ ENSMUSG00175007221
 protein coding gene Chr18:7159179-7276797 (-)
C57BL/6NJ ENSMUSG00215010700
 protein coding gene Chr18:6900961-7018610 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021991
 protein coding gene Chr18:6636535-6757663 (-)
CAST/EiJ ENSTCUG00005016271
 protein coding gene Chr18:7009087-7126940 (-)
CBA/J ENSMUSG00210021488
 protein coding gene Chr18:7172084-7289710 (-)
DBA/2J ENSMUSG00185028692
 protein coding gene Chr18:7179283-7296935 (-)
FVB/NJ ENSMUSG00205026519
 protein coding gene Chr18:6958487-7076132 (-)
JF1/MsJ ENSUMUG00000028393
 protein coding gene Chr18:7257145-7377089 (-)
LP/J ENSMUSG00230026529
 protein coding gene Chr18:9251098-9381343 (-)
NOD/ShiLtJ ENSMUSG00190009400
 protein coding gene Chr18:6952048-7069696 (-)
NZO/HlLtJ ENSMUSG00225033775
 protein coding gene Chr18:9162756-9280392 (-)
PWK/PhJ ENSLUMG00010008712
 protein coding gene Chr18:7446645-7566675 (-)
SPRET/EiJ ENSMSPG00010011640
 protein coding gene Chr18:7083683-7206563 (-)
WSB/EiJ ENSIUOG00005025742
 protein coding gene Chr18:7032979-7150608 (-)



Homology
more
  • Human Ortholog
    ROCK1, Rho associated coiled-coil containing protein kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROCK1, Rho associated coiled-coil containing protein kinase 1
  • Synonyms
    P160ROCK, ROCK-I
  • Links
    NCBI Gene ID: 6093
    UniProt: Q13464

  • Chr Location
    18q11.1; chr18:20944612-21111813 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 7 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    6 images
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have open eyes at birth, omphalocele and most die soon after birth as a result of cannibalization by the mom. Survivors develop inflammation of the eyelid. Another homozygous mutant shows partial lethality around implantation and reduced cardiac fibrosis after pressure overload.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    139
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    671
  • Tissues
    45
  • cDNA Data
    23
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024290 Ensembl Gene Model | MGI Sequence Detail 117645 C57BL/6J ±  kb
    transcript ENSMUST00000067947 Ensembl | MGI Sequence Detail 6440 Not Applicable  
    polypeptide ENSMUSP00000069549 Ensembl | MGI Sequence Detail 1354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 24
      Primer pair 5
      Antibodies 5

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-36507, MGI:1916035
    References
    more
    • Summaries
      All 238
      Developmental Gene Expression 31
      Gene Ontology 23
      Phenotypes 69
    • Earliest
      J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
    • Latest
      J:389429 Xiao B, et al., MAP3K1 integrates RhoA/ROCK signaling to regulate epithelial morphogenesis. iScience. 2026 Jun 19;29(6):115853
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory