Myh9 MGI Mouse Gene Detail - MGI:107717 - myosin, heavy polypeptide 9, non-muscle

Symbol

Myh9
Name

myosin, heavy polypeptide 9, non-muscle
Synonyms

D0Jmb2, E030044M24Rik, Fltn, Myhn-1, Myhn1, myosin IIA, NMHC II-A

Feature Type

protein coding gene
IDs

MGI:107717
NCBI Gene: 17886
Alliance

genome feature page
Transcription Start Sites

26 TSS
Regulated by

Rr243 (1 regulatory region)

Sequence Map

Chr15:77644788-77726315 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 36.81 cM
Mapping Data

3 experiments

SNPs within 2kb

2181 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107717	protein coding gene	Chr15:77644787-77726375 (-)
129S1/SvImJ	ENSMUSG00200052978	protein coding gene	Chr15:74760092-74812741 (-)
A/J	ENSMUSG00195046672	protein coding gene	Chr15:74702344-74754983 (-)
AKR/J	ENSMUSG00220050962	protein coding gene	Chr15:74745885-74798534 (-)
BALB/cJ	ENSMUSG00180044807	protein coding gene	Chr15:74579418-74632057 (-)
C3H/HeJ	ENSMUSG00175044623	protein coding gene	Chr15:74890815-74943451 (-)
C57BL/6NJ	ENSMUSG00215048160	protein coding gene	Chr15:74652000-74704647 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019970	protein coding gene	Chr15:71770094-71850348 (-)
CAST/EiJ	ENSTCUG00005042101	protein coding gene	Chr15:74202993-74255549 (-)
CBA/J	ENSMUSG00210045625	protein coding gene	Chr15:74666019-74718655 (-)
DBA/2J	ENSMUSG00185043850	protein coding gene	Chr15:74675435-74728071 (-)
FVB/NJ	ENSMUSG00205043234	protein coding gene	Chr15:74395538-74448180 (-)
JF1/MsJ	ENSUMUG00000045618	protein coding gene	Chr15:74245889-74298963 (-)
LP/J	ENSMUSG00230050135	protein coding gene	Chr15:78008641-78061276 (-)
NOD/ShiLtJ	ENSMUSG00190051481	protein coding gene	Chr15:74686944-74741554 (-)
NZO/HlLtJ	ENSMUSG00225051902	protein coding gene	Chr15:78337871-78392482 (-)
PWK/PhJ	ENSLUMG00010045476	protein coding gene	Chr15:74476974-74529832 (-)
SPRET/EiJ	ENSMSPG00010041961	protein coding gene	Chr15:76144027-76196359 (-)
WSB/EiJ	ENSIUOG00005047760	protein coding gene	Chr15:74732829-74785512 (-)

Human Ortholog

MYH9, myosin heavy chain 9

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYH9, myosin heavy chain 9
Synonyms

BDPLT6, DFNA17, EPSTS, FTNS, MATINS, MHA, NMHC-II-A, NMMHCA, NMMHC-IIA
Links

HGNC:7579

NCBI Gene ID: 4627

UniProt: P35579
Chr Location

22q12.3; chr22:36281279-36388010 (-) GRCh38

MGI Vertebrate Homology

Myh9 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYH9
Gene Tree

Myh9

Diseases

1 with Myh9 mouse models; 8 with human MYH9 associations

Human Disease

Mouse Models

MYH-9 related disease

IDs

View 4 models

Alport syndrome 3A

IDs

autosomal dominant nonsyndromic deafness 17

IDs

end stage renal disease

IDs

orofacial cleft

IDs

proteinuria

IDs

sensorineural hearing loss

IDs

thrombocytopenia

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

69 phenotypes from 15 alleles in 15 genetic backgrounds
3 images
126 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

309
Chemically induced (other)

2
Endonuclease-mediated

7
Gene trapped

278
Radiation induced

2
Targeted

20
Genomic Mutations

4 involving Myh9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

221 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display embryonic lethality. Heterozygous null mice display hearing loss with incomplete penetrance. Mice homozygous or heterozygous for one of several knock-in alleles exhibit macrothrombocytopenia, nephritis, cataracts and deafness.

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All GO Annotations

211
GO References

32

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

899
Tissues

102
cDNA Data

179
Literature Summary

53

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myh9

ZFIN myh9b

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All Sequences

90
RefSeq

2
UniProt

13
CCDS

CCDS27605.1

Ensembl

ENSMUSG00000022443 (Evidence)
NCBI Gene

17886

			Length	Strain/Species	Flank
genomic	17886	NCBI Gene Model \| MGI Sequence Detail	81528	C57BL/6J	± kb
transcript	NM_022410	RefSeq \| MGI Sequence Detail	7372	ZRU/MplStud
polypeptide	Q8VDD5	UniProt \| EBI \| MGI Sequence Detail	1960	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000010833 myosin-9

(term hierarchy)
InterPro Domains

IPR000048 IQ motif, EF-hand binding site

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain-like

IPR008989 Myosin S1 fragment, N-terminal

IPR004009 Myosin, SH3 domain

IPR002928 Myosin tail

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q8VDD5 3 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 184

cDNA 179

Primer pair 5

Antibodies 12

Microarray probesets 6

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MGD-MRK-12745, MGD-MRK-12749, MGD-MRK-36293, MGI:1206575, MGI:1344335, MGI:2146296, MGI:2443228, MGI:97257

Summaries

All 272

Developmental Gene Expression 53

Diseases 2

Gene Ontology 32

Phenotypes 126
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:391401 Creff J, et al., Goblet cells mechanically breach the epithelial barrier in gut homeostasis. Nat Commun. 2026 Jul 25;17(1)

Myh9 expression regulated by:

Feature	Feature Type	Location	Reference
Rr243, regulatory region 243	enhancer	Chr15:77789171-77790163	J:316526

TSS for Myh9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135137	Chr15:77726333-77726354 (-)	-29 bp
Tssr135136	Chr15:77726288-77726323 (-)	9 bp
Tssr135135	Chr15:77726247-77726258 (-)	62 bp
Tssr135129	Chr15:77713804-77713808 (-)	12,509 bp
Tssr135128	Chr15:77713655-77713658 (-)	12,658 bp
Tssr135127	Chr15:77700116-77700127 (-)	26,193 bp
Tssr135126	Chr15:77697403-77697437 (-)	28,895 bp
Tssr135125	Chr15:77697351-77697367 (-)	28,956 bp
Tssr135124	Chr15:77660126-77660143 (-)	66,180 bp
Tssr135123	Chr15:77659409-77659424 (-)	66,898 bp
Tssr135122	Chr15:77657595-77657618 (-)	68,708 bp
Tssr135121	Chr15:77656054-77656067 (-)	70,254 bp
Tssr135120	Chr15:77655410-77655427 (-)	70,896 bp
Tssr135119	Chr15:77655374-77655391 (-)	70,932 bp
Tssr135118	Chr15:77654073-77654092 (-)	72,232 bp
Tssr135117	Chr15:77651843-77651856 (-)	74,465 bp
Tssr135116	Chr15:77651767-77651793 (-)	74,535 bp
Tssr135115	Chr15:77651029-77651061 (-)	75,270 bp
Tssr135114	Chr15:77649966-77649980 (-)	76,342 bp
Tssr135113	Chr15:77648031-77648043 (-)	78,278 bp
Tssr135112	Chr15:77645967-77645983 (-)	80,340 bp
Tssr135111	Chr15:77645278-77645311 (-)	81,020 bp
Tssr135110	Chr15:77645190-77645213 (-)	81,113 bp
Tssr135109	Chr15:77645151-77645163 (-)	81,158 bp
Tssr135108	Chr15:77645067-77645150 (-)	81,206 bp
Tssr135107	Chr15:77644986-77645002 (-)	81,321 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24