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Kif3b Gene Detail
Summary
  • Symbol
    Kif3b
  • Name
    kinesin family member 3B
  • Synonyms
    mKIAA0359
  • Feature Type
    protein coding gene
  • IDs
    MGI:107688
    NCBI Gene: 16569
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:153133333-153175310 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.41 cM, cytoband G-H2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1077 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107688
 protein coding gene Chr2:153132028-153175310 (+)
129S1/SvImJ ENSMUSG00200029493
 protein coding gene Chr2:150048112-150090149 (+)
A/J ENSMUSG00195018134
 protein coding gene Chr2:150322006-150364549 (+)
AKR/J ENSMUSG00220042634
 protein coding gene Chr2:149643755-149685736 (+)
BALB/cJ ENSMUSG00180043037
 protein coding gene Chr2:149814230-149856241 (+)
C3H/HeJ ENSMUSG00175044016
 protein coding gene Chr2:150558469-150600476 (+)
C57BL/6NJ ENSMUSG00215032722
 protein coding gene Chr2:149978350-150020335 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024487
 protein coding gene Chr2:145172344-145215506 (+)
CAST/EiJ ENSTCUG00005039314
 protein coding gene Chr2:148899062-148942189 (+)
CBA/J ENSMUSG00210040847
 protein coding gene Chr2:150494992-150536989 (+)
DBA/2J ENSMUSG00185044353
 protein coding gene Chr2:150152046-150194572 (+)
FVB/NJ ENSMUSG00205022020
 protein coding gene Chr2:149238807-149280825 (+)
JF1/MsJ ENSUMUG00000031589
 protein coding gene Chr2:149810806-149853338 (+)
LP/J ENSMUSG00230034953
 protein coding gene Chr2:151796756-151838781 (+)
NOD/ShiLtJ ENSMUSG00190037898
 protein coding gene Chr2:149909842-149952370 (+)
NZO/HlLtJ ENSMUSG00225003677
 protein coding gene Chr2:159829060-159871040 (+)
PWK/PhJ ENSLUMG00010042733
 protein coding gene Chr2:149784695-149827867 (+)
SPRET/EiJ ENSMSPG00010027333
 protein coding gene Chr2:152502468-152546086 (+)
WSB/EiJ ENSIUOG00005041798
 protein coding gene Chr2:149643545-149685313 (+)



Homology
more
  • Human Ortholog
    KIF3B, kinesin family member 3B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF3B, kinesin family member 3B
  • Synonyms
    FLA8, HH0048, KLP-11, OTSC12, RP89
  • Links
    NCBI Gene ID: 9371
    UniProt: O15066

  • Chr Location
    20q11.21; chr20:32277651-32335011 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kif3b mouse models; 1 with human KIF3B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygoous for a targeted null mutation are growth retarded and display neural tube defects, incomplete embryo turning, randomized left-right assymetry, pericardial edema, and die during the midgestational period.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    705
  • Tissues
    51
  • cDNA Data
    103
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027475 Ensembl Gene Model | MGI Sequence Detail 41978 C57BL/6J ±  kb
    transcript ENSMUST00000028977 Ensembl | MGI Sequence Detail 5635 Not Applicable  
    polypeptide ENSMUSP00000028977 Ensembl | MGI Sequence Detail 747 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 105
      Primer pair 3
      Other 2
      Antibodies 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-36263, MGI:2139103, MGI:2139381
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 20
      Phenotypes 17
    • Earliest
      J:35066 Yamazaki H, et al., KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport. J Cell Biol. 1995 Sep;130(6):1387-99
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory