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Plxna2 Gene Detail
Summary
  • Symbol
    Plxna2
  • Name
    plexin A2
  • Synonyms
    2810428A13Rik, mKIAA0463, OCT, PlexA2, Plxn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107684
    NCBI Gene: 18845
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:194302020-194499177 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 98.27 cM, cytoband H6
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2890 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107684
 protein coding gene Chr1:194300526-194499177 (+)
129S1/SvImJ ENSMUSG00200004183
 protein coding gene Chr1:192095250-192292863 (+)
A/J ENSMUSG00195008259
 protein coding gene Chr1:191677825-191875167 (+)
AKR/J ENSMUSG00220004523
 protein coding gene Chr1:190925196-191122529 (+)
BALB/cJ ENSMUSG00180018274
 protein coding gene Chr1:191744745-191942096 (+)
C3H/HeJ ENSMUSG00175021776
 protein coding gene Chr1:191951917-192149250 (+)
C57BL/6NJ ENSMUSG00215016607
 protein coding gene Chr1:191138298-191335619 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015072
 protein coding gene Chr1:184618028-184814053 (+)
CAST/EiJ ENSTCUG00005001890
 protein coding gene Chr1:189706741-189901146 (+)
CBA/J ENSMUSG00210003504
 protein coding gene Chr1:191610770-191808111 (+)
DBA/2J ENSMUSG00185010003
 protein coding gene Chr1:196211502-196408838 (+)
FVB/NJ ENSMUSG00205003377
 protein coding gene Chr1:190579723-190777135 (+)
JF1/MsJ ENSUMUG00000007664
 protein coding gene Chr1:195189135-195383211 (+)
LP/J ENSMUSG00230002056
 protein coding gene Chr1:195714108-195911730 (+)
NOD/ShiLtJ ENSMUSG00190027933
 protein coding gene Chr1:191583399-191778441 (+)
NZO/HlLtJ ENSMUSG00225015800
 protein coding gene Chr1:199470008-199671094 (+)
PWK/PhJ ENSLUMG00010006345
 protein coding gene Chr1:190429368-190626770 (+)
SPRET/EiJ ENSMSPG00010024085
 protein coding gene Chr1:193930793-194128017 (+)
WSB/EiJ ENSIUOG00005004107
 protein coding gene Chr1:190902521-191099832 (+)



Homology
more
  • Human Ortholog
    PLXNA2, plexin A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLXNA2, plexin A2
  • Synonyms
    OCT, PLXN2
  • Links
    NCBI Gene ID: 5362
    UniProt: O75051

  • Chr Location
    1q32.2; chr1:208022242-208244850 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    998
  • Tissues
    244
  • cDNA Data
    25
  • Literature Summary
    98
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18845 NCBI Gene Model | MGI Sequence Detail 197158 C57BL/6J ±  kb
    transcript NM_008882 RefSeq | MGI Sequence Detail 11049 C57BL/6  
    polypeptide P70207 UniProt | EBI | MGI Sequence Detail 1894 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 26
      Primer pair 1
      Other 14
      Antibodies 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36259, MGI:1919991, MGI:2138117, MGI:2138589
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 98
      Gene Ontology 10
      Phenotypes 33
    • Earliest
      J:35259 Kameyama T, et al., Identification of plexin family molecules in mice. Biochem Biophys Res Commun. 1996 Sep 13;226(2):396-402
    • Latest
      J:381211 Zhao XF, et al., Diverse and location-specific roles of PlexinA2, PlexinA4, and NCAM in developing hippocampal mossy fibers. Transl Psychiatry. 2026 Feb 12;16(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory