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Ifna1 Gene Detail
Summary
  • Symbol
    Ifna1
  • Name
    interferon alpha 1
  • Synonyms
    Ifa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107668
    NCBI Gene: 15962
  • Member of
    Ifna cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:88768324-88768893 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 42.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107668
 protein coding gene Chr4:88768324-88768893 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028429
 protein coding gene Chr4:88538401-88538970 (-)
A/J MGP_AJ_G0028390
 protein coding gene Chr4:85457075-85457644 (-)
AKR/J MGP_AKRJ_G0028347
 protein coding gene Chr4:87770964-87771532 (+)
BALB/cJ MGP_BALBcJ_G0028418
 protein coding gene Chr4:85871020-85871541 (+)
C3H/HeJ MGP_C3HHeJ_G0028122
 protein coding gene Chr4:88290092-88290661 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028093
 protein coding gene Chr4:94750312-94750881 (-)
DBA/2J MGP_DBA2J_G0028243
 protein coding gene Chr4:85234565-85235134 (-)
FVB/NJ MGP_FVBNJ_G0028208
 protein coding gene Chr4:84166147-84166716 (-)
LP/J MGP_LPJ_G0028350
 protein coding gene Chr4:89047730-89048298 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028238
 protein coding gene Chr4:99764977-99765546 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028895
 protein coding gene Chr4:87914848-87915417 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0027110
 protein coding gene Chr4:85231413-85232659 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    IFNA1, interferon alpha 1
  • Vertebrate Orthologs
    20
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNA1, interferon alpha 1
  • Synonyms
    IFL, IFN, IFNA@, IFNA13, IFN-ALPHA, IFN-alphaD, leIF D
  • Links
    NCBI Gene ID: 3439
    neXtProt AC: NX_P01562
    UniProt: P01562

  • Chr Location
    9p21.3; chr9:21440439-21441316 (+)  GRCh38
  • Human Ortholog
    IFNA10, interferon alpha 10
  • Synonyms
    IFN-alphaC
  • Links
    NCBI Gene ID: 3446
    neXtProt AC: NX_P01566
    UniProt: P01566

  • Chr Location
    9p21.3; chr9:21206181-21207143 (-)  GRCh38
  • Human Ortholog
    IFNA13, interferon alpha 13
  • Links
    NCBI Gene ID: 3447
    neXtProt AC: NX_P01562
    UniProt: P01562

  • Chr Location
    9p21.3; chr9:21367372-21368057 (-)  GRCh38
  • Human Ortholog
    IFNA14, interferon alpha 14
  • Synonyms
    IFN-alphaH, LEIF2H
  • Links
    NCBI Gene ID: 3448
    neXtProt AC: NX_P01570
    UniProt: P01570

  • Chr Location
    9p21.3; chr9:21239002-21240005 (-)  GRCh38
  • Human Ortholog
    IFNA16, interferon alpha 16
  • Synonyms
    IFN-alpha-16, IFN-alphaO
  • Links
    NCBI Gene ID: 3449
    neXtProt AC: NX_P05015
    UniProt: P05015

  • Chr Location
    9p21.3; chr9:21216373-21217311 (-)  GRCh38
  • Human Ortholog
    IFNA17, interferon alpha 17
  • Synonyms
    IFNA, IFN-alphaI, INFA, LEIF2C1
  • Links
    NCBI Gene ID: 3451
    neXtProt AC: NX_P01571
    UniProt: P01571

  • Chr Location
    9p21.3; chr9:21227243-21228222 (-)  GRCh38
  • Human Ortholog
    IFNA2, interferon alpha 2
  • Synonyms
    IFNA, IFNA2B, IFN-alpha-2, IFN-alphaA, leIF A
  • Links
    NCBI Gene ID: 3440
    neXtProt AC: NX_P01563
    UniProt: P01563

  • Chr Location
    9p21.3; chr9:21384255-21385398 (-)  GRCh38
  • Human Ortholog
    IFNA21, interferon alpha 21
  • Synonyms
    IFN-alphaI, leIF-F, LeIF F
  • Links
    NCBI Gene ID: 3452
    neXtProt AC: NX_P01568
    UniProt: P01568

  • Chr Location
    9p21.3; chr9:21165637-21166660 (-)  GRCh38
  • Human Ortholog
    IFNA4, interferon alpha 4
  • Synonyms
    IFN-alpha4a, INFA4
  • Links
    NCBI Gene ID: 3441
    neXtProt AC: NX_P05014
    UniProt: P05014

  • Chr Location
    9p21.3; chr9:21186618-21187587 (-)  GRCh38
  • Human Ortholog
    IFNA5, interferon alpha 5
  • Synonyms
    IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF G
  • Links
    NCBI Gene ID: 3442
    neXtProt AC: NX_P01569
    UniProt: P01569

  • Chr Location
    9p21.3; chr9:21304326-21305313 (-)  GRCh38
  • Human Ortholog
    IFNA6, interferon alpha 6
  • Synonyms
    IFN-alphaK
  • Links
    NCBI Gene ID: 3443
    neXtProt AC: NX_P05013
    UniProt: P05013

  • Chr Location
    9p21.3; chr9:21350253-21350956 (-)  GRCh38
  • Human Ortholog
    IFNA7, interferon alpha 7
  • Synonyms
    IFNA-J, IFN-alphaJ
  • Links
    NCBI Gene ID: 3444
    neXtProt AC: NX_P01567
    UniProt: P01567

  • Chr Location
    9p21.3; chr9:21201469-21202205 (-)  GRCh38
  • Human Ortholog
    IFNA8, interferon alpha 8
  • Synonyms
    IFN-alphaB
  • Links
    NCBI Gene ID: 3445
    neXtProt AC: NX_P32881
    UniProt: P32881

  • Chr Location
    9p21.3; chr9:21409117-21410185 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human IFNA1,IFNA17,IFNA2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from multigenic genotypes
    21 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Radiation induced
    1
  • Transgenic
    2
  • Genomic Mutations
    5 involving Ifna1
  • Find Mice (IMSR)
    10 strains or lines available
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    5
  • cDNA Data
    1
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15962 NCBI Gene Model | MGI Sequence Detail 570 C57BL/6J ±  kb
transcript NM_010502 RefSeq | MGI Sequence Detail 570 Not Specified  
polypeptide P01572 UniProt | EBI | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 7
    cDNA 2
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11201, MGD-MRK-36243
References
more
  • Summaries
    All 86
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:25569 Aguet M, High-affinity binding of 125I-labelled mouse interferon to a specific cell surface receptor. Nature. 1980 Apr 3;284(5755):459-61
  • Latest
    J:346351 West PK, et al., Microglia shield the murine brain from damage mediated by the cytokines IL-6 and IFN-alpha. Front Immunol. 2022;13:1036799
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory