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Hsd17b3 Gene Detail
Summary
  • Symbol
    Hsd17b3
  • Name
    hydroxysteroid (17-beta) dehydrogenase 3
  • Synonyms
    17(beta)HSD type 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107177
    NCBI Gene: 15487
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:64206080-64237044 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 33.26 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107177
 protein coding gene Chr13:64206080-64237076 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020672
 protein coding gene Chr13:64065036-64097933 (-)
A/J MGP_AJ_G0020626
 protein coding gene Chr13:61741541-61777125 (-)
AKR/J MGP_AKRJ_G0020603
 protein coding gene Chr13:63789257-63821771 (-)
BALB/cJ MGP_BALBcJ_G0020624
 protein coding gene Chr13:62164859-62195723 (-)
C3H/HeJ MGP_C3HHeJ_G0020419
 protein coding gene Chr13:63316912-63348339 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021060
 protein coding gene Chr13:66133795-66164722 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018636
 protein coding gene Chr13:59397550-59429553 (-)
CAST/EiJ MGP_CASTEiJ_G0019936
 protein coding gene Chr13:63327644-63358490 (-)
CBA/J MGP_CBAJ_G0020379
 protein coding gene Chr13:68689805-68720625 (-)
DBA/2J MGP_DBA2J_G0020504
 protein coding gene Chr13:61575994-61610305 (-)
FVB/NJ MGP_FVBNJ_G0020483
 protein coding gene Chr13:60679819-60710608 (-)
LP/J MGP_LPJ_G0020578
 protein coding gene Chr13:64343749-64374639 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020512
 protein coding gene Chr13:67634147-67667869 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021102
 protein coding gene Chr13:63106032-63137646 (-)
PWK/PhJ MGP_PWKPhJ_G0019690
 protein coding gene Chr13:61127284-61158695 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019516
 protein coding gene Chr13:61267426-61298079 (-)
WSB/EiJ MGP_WSBEiJ_G0019996
 protein coding gene Chr13:63585934-63617467 (-)



Homology
more
  • Human Ortholog
    HSD17B3, hydroxysteroid 17-beta dehydrogenase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSD17B3, hydroxysteroid 17-beta dehydrogenase 3
  • Synonyms
    EDH17B3, SDR12C2
  • Links
    NCBI Gene ID: 3293
    neXtProt AC: NX_P37058
    UniProt: P37058

  • Chr Location
    9q22.32; chr9:96235306-96302176 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hsd17b3 mouse models; 2 with human HSD17B3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    19
  • cDNA Data
    3
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033122 Ensembl Gene Model | MGI Sequence Detail 30965 C57BL/6J ±  kb
    transcript ENSMUST00000222783 Ensembl | MGI Sequence Detail 1184 Not Applicable  
    polypeptide ENSMUSP00000152848 Ensembl | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 3
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35638
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:343800 Souali-Crespo S, et al., Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis. Development. 2023 Dec 15;150(24)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory