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Hsd17b3 Gene Detail
Summary
  • Symbol
    Hsd17b3
  • Name
    hydroxysteroid (17-beta) dehydrogenase 3
  • Synonyms
    17(beta)HSD type 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107177
    NCBI Gene: 15487
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:64206080-64237044 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 33.26 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    978 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107177
 protein coding gene Chr13:64206080-64237076 (-)
129S1/SvImJ ENSMUSG00200015784
 protein coding gene Chr13:60346654-60377576 (-)
A/J ENSMUSG00195042462
 protein coding gene Chr13:60506165-60537039 (-)
AKR/J ENSMUSG00220035265
 protein coding gene Chr13:59588286-59619213 (-)
BALB/cJ ENSMUSG00180024584
 protein coding gene Chr13:60802864-60833778 (-)
C3H/HeJ ENSMUSG00175006589
 protein coding gene Chr13:60627929-60658809 (-)
C57BL/6NJ ENSMUSG00215011726
 protein coding gene Chr13:60617193-60648151 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018636
 protein coding gene Chr13:59397550-59429553 (-)
CAST/EiJ ENSTCUG00005011493
 protein coding gene Chr13:61000014-61030879 (-)
CBA/J ENSMUSG00210008401
 protein coding gene Chr13:60827361-60858240 (-)
DBA/2J ENSMUSG00185007920
 protein coding gene Chr13:61666308-61697205 (-)
FVB/NJ ENSMUSG00205028504
 protein coding gene Chr13:59801722-59832630 (-)
JF1/MsJ ENSUMUG00000017708
 protein coding gene Chr13:61275225-61306183 (-)
LP/J ENSMUSG00230033839
 protein coding gene Chr13:71016775-71047878 (-)
NOD/ShiLtJ ENSMUSG00190032458
 protein coding gene Chr13:60575581-60606478 (-)
NZO/HlLtJ ENSMUSG00225045515
 protein coding gene Chr13:64726979-64758067 (-)
PWK/PhJ ENSLUMG00010019375
 protein coding gene Chr13:60121993-60152958 (-)
SPRET/EiJ ENSMSPG00010034003
 protein coding gene Chr13:60345796-60376163 (-)
WSB/EiJ ENSIUOG00005021940
 protein coding gene Chr13:59296988-59327903 (-)



Homology
more
  • Human Ortholog
    HSD17B3, hydroxysteroid 17-beta dehydrogenase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSD17B3, hydroxysteroid 17-beta dehydrogenase 3
  • Synonyms
    EDH17B3, SDR12C2
  • Links
    NCBI Gene ID: 3293
    UniProt: P37058

  • Chr Location
    9q22.32; chr9:96235306-96302176 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hsd17b3 mouse models; 2 with human HSD17B3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    647
  • Tissues
    25
  • cDNA Data
    3
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033122 Ensembl Gene Model | MGI Sequence Detail 30965 C57BL/6J ±  kb
    transcript ENSMUST00000222783 Ensembl | MGI Sequence Detail 1184 Not Applicable  
    polypeptide ENSMUSP00000152848 Ensembl | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 3
      Primer pair 4
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35638
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 24
      Diseases 1
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:391700 Junnila A, et al., Testosterone Exposure During Fetal Masculinization Programming Window Determines the Kidney Size in Adult Mice. FASEB J. 2026 Apr 15;40(7):e71724
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory