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Cyp7a1 Gene Detail
Summary
  • Symbol
    Cyp7a1
  • Name
    cytochrome P450, family 7, subfamily a, polypeptide 1
  • Synonyms
    cholesterol 7 alpha hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:106091
    NCBI Gene: 13122
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:6265612-6275632 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 2.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    363 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106091
 protein coding gene Chr4:6265612-6275633 (-)
129S1/SvImJ ENSMUSG00200000844
 protein coding gene Chr4:2881442-2891646 (-)
A/J ENSMUSG00195002601
 protein coding gene Chr4:3330593-3340805 (-)
AKR/J ENSMUSG00220001245
 protein coding gene Chr4:3095649-3105853 (-)
BALB/cJ ENSMUSG00180004087
 protein coding gene Chr4:2877845-2888051 (-)
C3H/HeJ ENSMUSG00175016984
 protein coding gene Chr4:3411920-3421939 (-)
C57BL/6NJ ENSMUSG00215004289
 protein coding gene Chr4:2994649-3004669 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025791
 protein coding gene Chr4:2541385-2551952 (-)
CAST/EiJ ENSTCUG00005025915
 protein coding gene Chr4:3188279-3198495 (-)
CBA/J ENSMUSG00210002218
 protein coding gene Chr4:3153527-3163546 (-)
DBA/2J ENSMUSG00185002518
 protein coding gene Chr4:3274834-3284854 (-)
FVB/NJ ENSMUSG00205003281
 protein coding gene Chr4:2932270-2942474 (-)
JF1/MsJ ENSUMUG00000001269
 protein coding gene Chr4:3401545-3413077 (-)
LP/J ENSMUSG00230008386
 protein coding gene Chr4:6434436-6444640 (-)
NOD/ShiLtJ ENSMUSG00190012682
 protein coding gene Chr4:2973960-2984164 (-)
NZO/HlLtJ ENSMUSG00225008001
 protein coding gene Chr4:10417037-10427056 (-)
PWK/PhJ ENSLUMG00010005438
 protein coding gene Chr4:2891052-2902543 (-)
SPRET/EiJ ENSMSPG00010002509
 protein coding gene Chr4:3117213-3127306 (-)
WSB/EiJ ENSIUOG00005013304
 protein coding gene Chr4:2909755-2919773 (-)



Homology
more
  • Human Ortholog
    CYP7A1, cytochrome P450 family 7 subfamily A member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP7A1, cytochrome P450 family 7 subfamily A member 1
  • Synonyms
    CP7A, CYP7, CYPVII
  • Links
    NCBI Gene ID: 1581
    UniProt: P22680

  • Chr Location
    8q12.1; chr8:58490178-58500163 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene experience severe neonatal and postnatal lethality. Supplementation of the maternal diet with fat soluble vitamins and cholic acid starting before birth alleviates much of the phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    613
  • Tissues
    5
  • cDNA Data
    18
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13122 NCBI Gene Model | MGI Sequence Detail 10021 C57BL/6J ±  kb
    transcript NM_007824 RefSeq | MGI Sequence Detail 4173 C57BL/6  
    polypeptide Q64505 UniProt | EBI | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 3
      cDNA 18
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33776
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 14
      Gene Ontology 16
      Phenotypes 26
    • Earliest
      J:18307 Tzung KW, et al., Structure of the mouse cholesterol 7 alpha-hydroxylase gene. Genomics. 1994 May 1;21(1):244-7
    • Latest
      J:389099 Lin H, et al., The enterohepatic bile acid axis: from perinatal programming to metabolic collapse. Biochem Biophys Res Commun. 2026 Jul 9;830:154261
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory