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Meis1 Gene Detail
Summary
  • Symbol
    Meis1
  • Name
    Meis homeobox 1
  • Synonyms
    C530044H18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:104717
    NCBI Gene: 17268
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:18830428-18968992 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 11.11 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3042 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104717
 protein coding gene Chr11:18829817-18968992 (-)
129S1/SvImJ ENSMUSG00200021873
 protein coding gene Chr11:15839927-15979077 (-)
A/J ENSMUSG00195005063
 protein coding gene Chr11:15667792-15807087 (-)
AKR/J ENSMUSG00220002865
 protein coding gene Chr11:15757175-15896461 (-)
BALB/cJ ENSMUSG00180003706
 protein coding gene Chr11:15665220-15804494 (-)
C3H/HeJ ENSMUSG00175007498
 protein coding gene Chr11:15704200-15843453 (-)
C57BL/6NJ ENSMUSG00215003302
 protein coding gene Chr11:15768584-15907771 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016112
 protein coding gene Chr11:14824519-14964933 (-)
CAST/EiJ ENSTCUG00005007153
 protein coding gene Chr11:15657189-15797078 (-)
CBA/J ENSMUSG00210009142
 protein coding gene Chr11:15681398-15820740 (-)
DBA/2J ENSMUSG00185011012
 protein coding gene Chr11:15795630-15934888 (-)
FVB/NJ ENSMUSG00205004342
 protein coding gene Chr11:15720775-15860039 (-)
JF1/MsJ ENSUMUG00000005019
 protein coding gene Chr11:15974288-16114007 (-)
LP/J ENSMUSG00230004122
 protein coding gene Chr11:16815712-16954996 (-)
NOD/ShiLtJ ENSMUSG00190008249
 protein coding gene Chr11:15791606-15930846 (-)
NZO/HlLtJ ENSMUSG00225032770
 protein coding gene Chr11:18831747-18971004 (-)
PWK/PhJ ENSLUMG00010011334
 protein coding gene Chr11:15632926-15772585 (-)
SPRET/EiJ ENSMSPG00010017672
 protein coding gene Chr11:15910105-16050453 (-)
WSB/EiJ ENSIUOG00005009951
 protein coding gene Chr11:15734494-15873597 (-)



Homology
more
  • Human Ortholog
    MEIS1, Meis homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEIS1, Meis homeobox 1
  • Links
    NCBI Gene ID: 4211
    UniProt: O00470

  • Chr Location
    2p14; chr2:66433452-66573898 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Meis1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 7 alleles in 9 genetic backgrounds
    17 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die during gestation and exhibit eye, vasculature, and hematopoietic defects. Mice homozygous for a conditional allele activated in HSCs exhibit altered bone marrow cell development, altered HSC physiology and increased reactive oxygen species production. Homozygosity for the p.R272H mutation affects sleeping behavior in aged mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1428
  • Tissues
    413
  • cDNA Data
    34
  • Literature Summary
    150
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17268 NCBI Gene Model | MGI Sequence Detail 138565 C57BL/6J ±  kb
    transcript NM_001193271 RefSeq | MGI Sequence Detail 3441 ZRU/MplStud  
    polypeptide Q60954 UniProt | EBI | MGI Sequence Detail 390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 9
      cDNA 37
      Primer pair 9
      Other 20
      Antibodies 12

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-27080, MGI:2443806
    References
    more
    • Summaries
      All 274
      Developmental Gene Expression 150
      Diseases 2
      Gene Ontology 29
      Phenotypes 62
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:383294 Smolikova J, et al., Meis1 and Meis2 are jointly required for advanced stages of mouse lens morphogenesis. Dev Biol. 2026 Apr 16;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory