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Wee1 Gene Detail
Summary
  • Symbol
    Wee1
  • Name
    WEE 1 homolog 1 (S. pombe)
  • Synonyms
    Wee1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:103075
    NCBI Gene: 22390
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:109721266-109742506 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.70 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103075
 protein coding gene Chr7:109721253-109742506 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032855
 protein coding gene Chr7:113586965-113606736 (+)
A/J MGP_AJ_G0032839
 protein coding gene Chr7:110770617-110791199 (+)
AKR/J MGP_AKRJ_G0032770
 protein coding gene Chr7:113558549-113579905 (+)
BALB/cJ MGP_BALBcJ_G0032843
 protein coding gene Chr7:110468875-110488769 (+)
C3H/HeJ MGP_C3HHeJ_G0032553
 protein coding gene Chr7:113587175-113606873 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033349
 protein coding gene Chr7:118296263-118317693 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030321
 protein coding gene Chr7:112352197-112372195 (+)
CAST/EiJ MGP_CASTEiJ_G0031881
 protein coding gene Chr7:105147142-105168471 (+)
CBA/J MGP_CBAJ_G0032526
 protein coding gene Chr7:122162745-122182503 (+)
DBA/2J MGP_DBA2J_G0032678
 protein coding gene Chr7:108879849-108899682 (+)
FVB/NJ MGP_FVBNJ_G0032631
 protein coding gene Chr7:108737077-108756988 (+)
LP/J MGP_LPJ_G0032772
 protein coding gene Chr7:115122096-115145489 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032663
 protein coding gene Chr7:123814151-123835367 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033370
 protein coding gene Chr7:112568842-112589116 (+)
PWK/PhJ MGP_PWKPhJ_G0031588
 protein coding gene Chr7:101699207-101719658 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031436
 protein coding gene Chr7:99270031-99289392 (+)
WSB/EiJ MGP_WSBEiJ_G0031994
 protein coding gene Chr7:113423275-113444190 (+)



Homology
more
  • Human Ortholog
    WEE1, WEE1 G2 checkpoint kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WEE1, WEE1 G2 checkpoint kinase
  • Synonyms
    WEE1A, WEE1hu
  • Links
    NCBI Gene ID: 7465
    neXtProt AC: NX_P30291
    UniProt: P30291

  • Chr Location
    11p15.4; chr11:9573670-9593457 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption may exhibit embryonic lethality at E7. Mice homozygous for a knock-out allele exhibit lethality between E3.5 and E7.5 with reduced proliferation, increased apoptosis and abnormal G2/M checkpoint function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    22
  • cDNA Data
    86
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22390 NCBI Gene Model | MGI Sequence Detail 21241 C57BL/6J ±  kb
    transcript NM_009516 RefSeq | MGI Sequence Detail 3419 C57BL/6  
    polypeptide P47810 UniProt | EBI | MGI Sequence Detail 646 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      Genomic 1
      cDNA 88
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-23939
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 11
      Gene Ontology 11
      Phenotypes 25
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:334092 Broadway-Stringer S, et al., Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2. Cells. 2023 Feb 24;12(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory