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Fosl2 Gene Detail
Summary
  • Symbol
    Fosl2
  • Name
    fos-like antigen 2
  • Synonyms
    Fra-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102858
    NCBI Gene: 14284
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:32293145-32315186 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102858
 protein coding gene Chr5:32292599-32315186 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029433
 protein coding gene Chr5:30200339-30224113 (+)
A/J MGP_AJ_G0029399
 protein coding gene Chr5:29208052-29230090 (+)
AKR/J MGP_AKRJ_G0029349
 protein coding gene Chr5:30371882-30393904 (+)
BALB/cJ MGP_BALBcJ_G0029410
 protein coding gene Chr5:29736171-29758213 (+)
C3H/HeJ MGP_C3HHeJ_G0029131
 protein coding gene Chr5:30384029-30408424 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029863
 protein coding gene Chr5:32004578-32026626 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027101
 protein coding gene Chr5:26872655-26894693 (+)
CAST/EiJ MGP_CASTEiJ_G0028541
 protein coding gene Chr5:29471619-29495045 (+)
CBA/J MGP_CBAJ_G0029099
 protein coding gene Chr5:32669651-32691738 (+)
DBA/2J MGP_DBA2J_G0029248
 protein coding gene Chr5:29381964-29404007 (+)
FVB/NJ MGP_FVBNJ_G0029206
 protein coding gene Chr5:28794968-28817097 (+)
LP/J MGP_LPJ_G0029333
 protein coding gene Chr5:30640049-30662089 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029235
 protein coding gene Chr5:33493734-33518381 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029897
 protein coding gene Chr5:29867406-29889529 (+)
PWK/PhJ MGP_PWKPhJ_G0028266
 protein coding gene Chr5:28532769-28555495 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028097
 protein coding gene Chr5:29347958-29370228 (+)
WSB/EiJ MGP_WSBEiJ_G0028622
 protein coding gene Chr5:29951134-29974915 (+)



Homology
more
  • Human Ortholog
    FOSL2, FOS like 2, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOSL2, FOS like 2, AP-1 transcription factor subunit
  • Synonyms
    FRA2
  • Links
    NCBI Gene ID: 2355
    neXtProt AC: NX_P15408
    UniProt: P15408

  • Chr Location
    2p23.2; chr2:28392448-28417317 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 6 genetic backgrounds
    41 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die within one week after birth and show postnatal growth retardation. Further analysis of one allele showed abnormal cartilage development, with delayed bone ossification and impaired chondrocyte differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    102
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1166
  • Tissues
    241
  • cDNA Data
    14
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029135 Ensembl Gene Model | MGI Sequence Detail 22042 C57BL/6J ±  kb
    transcript ENSMUST00000031017 Ensembl | MGI Sequence Detail 6537 Not Applicable  
    polypeptide ENSMUSP00000031017 Ensembl | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 9
      cDNA 15
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-23691
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 16
      Diseases 3
      Gene Ontology 25
      Phenotypes 54
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:344603 Stellato M, et al., The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions. Commun Biol. 2023 Feb 9;6(1):161
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory