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Entpd1 Gene Detail
Summary
  • Symbol
    Entpd1
  • Name
    ectonucleoside triphosphate diphosphohydrolase 1
  • Synonyms
    2610206B08Rik, Cd39, ectoapyrase, NTPDase-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102805
    NCBI Gene: 12495
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:40600810-40730046 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 34.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    874 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102805
 protein coding gene Chr19:40600810-40730046 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025114
 protein coding gene Chr19:39828419-39977242 (+)
A/J MGP_AJ_G0025091
 protein coding gene Chr19:37888042-38035975 (+)
AKR/J MGP_AKRJ_G0025059
 protein coding gene Chr19:39179577-39319495 (+)
BALB/cJ MGP_BALBcJ_G0025085
 protein coding gene Chr19:37978940-38109774 (+)
C3H/HeJ MGP_C3HHeJ_G0024845
 protein coding gene Chr19:39322336-39458674 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025529
 protein coding gene Chr19:40910914-41058612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022942
 protein coding gene Chr19:37297316-37425325 (+)
CAST/EiJ MGP_CASTEiJ_G0024310
 protein coding gene Chr19:38953270-39084865 (+)
CBA/J MGP_CBAJ_G0024825
 protein coding gene Chr19:42903550-43057586 (+)
DBA/2J MGP_DBA2J_G0024957
 protein coding gene Chr19:37792797-37923915 (+)
FVB/NJ MGP_FVBNJ_G0024918
 protein coding gene Chr19:37544282-37677490 (+)
LP/J MGP_LPJ_G0025043
 protein coding gene Chr19:39867971-40004848 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024949
 protein coding gene Chr19:42597751-42740781 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025586
 protein coding gene Chr19:39210054-39345016 (+)
PWK/PhJ MGP_PWKPhJ_G0024060
 protein coding gene Chr19:37637193-37768376 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023863
 protein coding gene Chr19:37937317-38073295 (+)
WSB/EiJ MGP_WSBEiJ_G0024380
 protein coding gene Chr19:39372416-39511552 (+)



Homology
more
  • Human Ortholog
    ENTPD1, ectonucleoside triphosphate diphosphohydrolase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENTPD1, ectonucleoside triphosphate diphosphohydrolase 1
  • Synonyms
    ATPDase, ATP-DPH, CD39, NTPDase-1, SPG64
  • Links
    NCBI Gene ID: 953
    neXtProt AC: NX_P49961
    UniProt: P49961

  • Chr Location
    10q24.1; chr10:95694186-95877266 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ENTPD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 5 genetic backgrounds
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in muscle contraction, synaptic transmitter release and blood coagulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    842
  • Tissues
    111
  • cDNA Data
    57
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12495 NCBI Gene Model | MGI Sequence Detail 129237 C57BL/6J ±  kb
    transcript NM_001304721 RefSeq | MGI Sequence Detail 4248 C57BL/6  
    polypeptide P55772 UniProt | EBI | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 5
      cDNA 57
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-19713, MGI:1919726, MGI:2147438
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 78
    • Earliest
      J:20864 Maliszewski CR, et al., The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J Immunol. 1994 Oct 15;153(8):3574-83
    • Latest
      J:336691 El-Naccache DW, et al., Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering A2BAR signaling in intestinal epithelial cells. Cell Rep. 2022 Aug 2;40(5):111150
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory