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Pla2g5 Gene Detail
Summary
  • Symbol
    Pla2g5
  • Name
    phospholipase A2, group V
  • Synonyms
    sPLA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101899
    NCBI Gene: 18784
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:138526558-138590780 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.57 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    843 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101899
protein coding gene Chr4:138526555-138590793 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029004
protein coding gene Chr4:141585204-141655884 (-)
A/J MGP_AJ_G0028963
protein coding gene Chr4:135508353-135574554 (-)
AKR/J MGP_AKRJ_G0028915
protein coding gene Chr4:139386051-139451319 (-)
BALB/cJ MGP_BALBcJ_G0028987
protein coding gene Chr4:136184063-136249944 (-)
C3H/HeJ MGP_C3HHeJ_G0028701
protein coding gene Chr4:139759286-139826897 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029428
protein coding gene Chr4:146591775-146680821 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026699
protein coding gene Chr4:128488825-128549295 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028666
protein coding gene Chr4:150816712-150895239 (-)
DBA/2J MGP_DBA2J_G0028815
protein coding gene Chr4:135891235-135957435 (-)
FVB/NJ MGP_FVBNJ_G0028782
protein coding gene Chr4:134920125-134987436 (-)
LP/J MGP_LPJ_G0028914
protein coding gene Chr4:141666031-141737891 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028808
protein coding gene Chr4:154771965-154840388 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029466
protein coding gene Chr4:139918202-139986774 (-)
PWK/PhJ MGP_PWKPhJ_G0027854
protein coding gene Chr4:132749215-132818785 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027679
protein coding gene Chr4:135674161-135744726 (-)
WSB/EiJ MGP_WSBEiJ_G0028211
protein coding gene Chr4:140156113-140225785 (-)



Homology
more
  • Human Ortholog
    PLA2G5, phospholipase A2 group V
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G5, phospholipase A2 group V
  • Synonyms
    FRFB, GV-PLA2, hVPLA(2), PLA2-10
  • Links
    NCBI Gene ID: 5322
    neXtProt AC: NX_P39877
    UniProt: P39877

  • Chr Location
    1p36.13; chr1:20028179-20091911 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human PLA2G5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 5 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced acute zymosan-induced peritonitis and arachadonic acid metabolite release from stimulated peritoneal macrophages. Mice homozygous for a different knock-out allele exhibit reduced response to myocardial ischemia/reperfusion injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18784 NCBI Gene Model | MGI Sequence Detail 64223 C57BL/6J ±  kb
    transcript NM_001122954 RefSeq | MGI Sequence Detail 2137 C57BL/6  
    polypeptide P97391 UniProt | EBI | MGI Sequence Detail 137 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 2
      cDNA 11

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18726
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 36
    • Earliest
      J:30355 Dennis EA, Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem. 1994 May 6;269(18):13057-60
    • Latest
      J:301978 Watanabe K, et al., Group V secreted phospholipase A2 plays a protective role against aortic dissection. J Biol Chem. 2020 Jul 24;295(30):10092-10111

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory