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Traf2 Gene Detail
Summary
  • Symbol
    Traf2
  • Name
    TNF receptor-associated factor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101835
    NCBI Gene: 22030
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25407994-25436952 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101835
 protein coding gene Chr2:25407994-25436952 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025453
 protein coding gene Chr2:23414081-23444439 (-)
A/J MGP_AJ_G0025430
 protein coding gene Chr2:22504244-22533683 (-)
AKR/J MGP_AKRJ_G0025400
 protein coding gene Chr2:23269984-23304458 (-)
BALB/cJ MGP_BALBcJ_G0025426
 protein coding gene Chr2:22617428-22655072 (-)
C3H/HeJ MGP_C3HHeJ_G0025187
 protein coding gene Chr2:23201459-23232126 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025870
 protein coding gene Chr2:24157041-24187434 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023281
 protein coding gene Chr2:21415510-21445480 (-)
CAST/EiJ MGP_CASTEiJ_G0024650
 protein coding gene Chr2:23068461-23099825 (-)
CBA/J MGP_CBAJ_G0025165
 protein coding gene Chr2:24993624-25023366 (-)
DBA/2J MGP_DBA2J_G0025298
 protein coding gene Chr2:22342814-22375106 (-)
FVB/NJ MGP_FVBNJ_G0025260
 protein coding gene Chr2:22088069-22123133 (-)
LP/J MGP_LPJ_G0025384
 protein coding gene Chr2:23349617-23383803 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025291
 protein coding gene Chr2:25188737-25220030 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025929
 protein coding gene Chr2:23211940-23243867 (-)
PWK/PhJ MGP_PWKPhJ_G0024398
 protein coding gene Chr2:22166392-22196376 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024198
 protein coding gene Chr2:23352293-23388046 (-)
WSB/EiJ MGP_WSBEiJ_G0024719
 protein coding gene Chr2:23282313-23314188 (-)



Homology
more
  • Human Ortholog
    TRAF2, TNF receptor associated factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAF2, TNF receptor associated factor 2
  • Synonyms
    MGC:45012, RNF117, TRAP, TRAP3
  • Links
    NCBI Gene ID: 7186
    neXtProt AC: NX_Q12933
    UniProt: Q12933

  • Chr Location
    9q34.3; chr9:136881912-136926607 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 4 alleles in 8 genetic backgrounds
    22 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Increased lethaltiy is observed with homozygous null mice. Offspring are runted and exhibit atrophic thymii and spleens with reduced numbers of lymphocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    118
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    41
  • cDNA Data
    64
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22030 NCBI Gene Model | MGI Sequence Detail 28959 C57BL/6J ±  kb
    transcript NM_001290413 RefSeq | MGI Sequence Detail 3065 C57BL/6  
    polypeptide P39429 UniProt | EBI | MGI Sequence Detail 501 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 1
      cDNA 64
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18656, MGI:2138907
    References
    more
    • Summaries
      All 173
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 34
      Phenotypes 55
    • Earliest
      J:19898 Rothe M, et al., A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 1994 Aug 26;78(4):681-92
    • Latest
      J:342771 Harit K, et al., The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2. Cell Death Dis. 2023 Jul 29;14(7):480
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory