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Nes Gene Detail
Summary
  • Symbol
    Nes
  • Name
    nestin
  • Synonyms
    ESTM46, Ifaprc2, Marc2, RC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101784
    NCBI Gene: 18008
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87878400-87887758 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101784
 protein coding gene Chr3:87878385-87887758 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027377
 protein coding gene Chr3:88105157-88114530 (+)
A/J MGP_AJ_G0027341
 protein coding gene Chr3:85114884-85124711 (+)
AKR/J MGP_AKRJ_G0027307
 protein coding gene Chr3:87207952-87217593 (+)
BALB/cJ MGP_BALBcJ_G0027350
 protein coding gene Chr3:85208447-85218088 (+)
C3H/HeJ MGP_C3HHeJ_G0027093
 protein coding gene Chr3:87483297-87492939 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027796
 protein coding gene Chr3:91345616-91355253 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025149
 protein coding gene Chr3:80746043-80755717 (+)
CAST/EiJ MGP_CASTEiJ_G0026539
 protein coding gene Chr3:87693422-87702661 (+)
CBA/J MGP_CBAJ_G0027068
 protein coding gene Chr3:94439908-94449286 (+)
DBA/2J MGP_DBA2J_G0027204
 protein coding gene Chr3:84605421-84614798 (+)
FVB/NJ MGP_FVBNJ_G0027173
 protein coding gene Chr3:82878172-82887550 (+)
LP/J MGP_LPJ_G0027312
 protein coding gene Chr3:89071965-89081338 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027192
 protein coding gene Chr3:100694925-100704303 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027854
 protein coding gene Chr3:86962429-86971675 (+)
PWK/PhJ MGP_PWKPhJ_G0026272
 protein coding gene Chr3:84401073-84410309 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026090
 protein coding gene Chr3:86143524-86153114 (+)
WSB/EiJ MGP_WSBEiJ_G0026619
 protein coding gene Chr3:87323931-87333304 (+)



Homology
more
  • Human Ortholog
    NES, nestin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NES, nestin
  • Synonyms
    Nbla00170
  • Links
    NCBI Gene ID: 10763
    neXtProt AC: NX_P48681
    UniProt: P48681

  • Chr Location
    1q23.1; chr1:156668763-156677407 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 5 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some mice homozygous for a knock-out allele display a high incidence of embryonic lethality, reduced embryo and birth body size, and fewer neural stem cells and increased apoptosis in the neuroepithelium of the developing neural tube. However, mice homozygous for another null allele are viable and show no obvious phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1950
  • Tissues
    414
  • cDNA Data
    120
  • Literature Summary
    993
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18008 NCBI Gene Model | MGI Sequence Detail 9359 C57BL/6J ±  kb
    transcript NM_016701 RefSeq | MGI Sequence Detail 6143 ZRU/MplStud  
    polypeptide Q6P5H2 UniProt | EBI | MGI Sequence Detail 1864 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 150
      cDNA 125
      Primer pair 21
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18592, MGI:1334428, MGI:1345191, MGI:1929610, MGI:2140057
    References
    more
    • Summaries
      All 1104
      Developmental Gene Expression 993
      Diseases 1
      Gene Ontology 15
      Phenotypes 24
    • Earliest
      J:70573 Misson JP, et al., Identification of radial glial cells within the developing murine central nervous system: studies based upon a new immunohistochemical marker. Brain Res Dev Brain Res. 1988 Nov 1;44(1):95-108
    • Latest
      J:346066 Rasool D, et al., PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS. EMBO Rep. 2024 Mar;25(3):1256-1281
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory