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Vcp Gene Detail
Summary
  • Symbol
    Vcp
  • Name
    valosin containing protein
  • Synonyms
    AAA ATPase p97, CDC48, p97, p97/VCP
  • Feature Type
    protein coding gene
  • IDs
    MGI:99919
    NCBI Gene: 269523
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:42979964-43000507 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 22.95 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    521 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99919
 protein coding gene Chr4:42979963-43000507 (-)
129S1/SvImJ ENSMUSG00200004670
 protein coding gene Chr4:39016055-39036594 (-)
A/J ENSMUSG00195002788
 protein coding gene Chr4:39498721-39519260 (-)
AKR/J ENSMUSG00220033217
 protein coding gene Chr4:39182350-39202890 (-)
BALB/cJ ENSMUSG00180023262
 protein coding gene Chr4:39085493-39106032 (-)
C3H/HeJ ENSMUSG00175021090
 protein coding gene Chr4:39229836-39250375 (-)
C57BL/6NJ ENSMUSG00215017540
 protein coding gene Chr4:38996802-39017347 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025925
 protein coding gene Chr4:37082745-37104022 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210007178
 protein coding gene Chr4:38916310-38936849 (-)
DBA/2J ENSMUSG00185006040
 protein coding gene Chr4:39279776-39300315 (-)
FVB/NJ ENSMUSG00205023524
 protein coding gene Chr4:38522995-38543534 (-)
JF1/MsJ ENSUMUG00000015638
 protein coding gene Chr4:39523695-39544232 (-)
LP/J ENSMUSG00230037192
 protein coding gene Chr4:42827752-42848292 (-)
NOD/ShiLtJ ENSMUSG00190005282
 protein coding gene Chr4:39140716-39161255 (-)
NZO/HlLtJ ENSMUSG00225006187
 protein coding gene Chr4:47427784-47448322 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010020694
 protein coding gene Chr4:39449455-39469826 (-)
WSB/EiJ ENSIUOG00005048352
 protein coding gene Chr4:38893762-38914296 (-)



Homology
more
  • Human Ortholog
    VCP, valosin containing protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VCP, valosin containing protein
  • Synonyms
    CDC48, FTDALS6, p97, TERA
  • Links
    NCBI Gene ID: 7415
    UniProt: P55072

  • Chr Location
    9p13.3; chr9:35053928-35072671 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Vcp mouse models; 6 with human VCP associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 6 alleles in 8 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality before weaning. Mice homozygous for a knock-in allele exhibit progressive muscle weakness, myopathy, decreased bone density, increased osteoclast genesis, and seizures. Heterozygosity for p.T262A mutation affects neural stem cells and leads to neurological defects. Heterozygosity for p.A232E mutation reduces sensitivity to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    279
  • GO References
    47
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    669
  • Tissues
    30
  • cDNA Data
    24
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269523 NCBI Gene Model | MGI Sequence Detail 20544 C57BL/6J ±  kb
    transcript NM_009503 RefSeq | MGI Sequence Detail 3315 ZRU/MplStud  
    polypeptide Q01853 UniProt | EBI | MGI Sequence Detail 806 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 6
      cDNA 25
      Primer pair 1
      Antibodies 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16720
    References
    more
    • Summaries
      All 192
      Developmental Gene Expression 8
      Diseases 3
      Gene Ontology 47
      Phenotypes 43
    • Earliest
      J:2369 Egerton M, et al., VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation. EMBO J. 1992 Oct;11(10):3533-40
    • Latest
      J:365810 Sun X, et al., Cardiac-Specific Suppression of Valosin-Containing Protein Induces Progressive Heart Failure and Premature Mortality Correlating with Temporal Dysregulations in mTOR Complex 2 and Protein Phosphatase 1. Int J Mol Sci. 2024 Jun 11;25(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory