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Myh6 Gene Detail
Summary
  • Symbol
    Myh6
  • Name
    myosin, heavy polypeptide 6, cardiac muscle, alpha
  • Synonyms
    A830009F23Rik, alpha cardiac MHC, alpha-MHC, alphaMHC, alpha myosin, cardiomyopathy, hypertrophic 1, Myhc-a, Myhca
  • Feature Type
    protein coding gene
  • IDs
    MGI:97255
    NCBI Gene: 17888
  • Alliance
  • Transcription Start Sites
    78 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55179378-55204384 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.01 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    781 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97255
protein coding gene Chr14:55179378-55205553 (-)
129S1/SvImJ ENSMUSG00200039858
protein coding gene Chr14:43759623-43783116 (-)
A/J ENSMUSG00195027791
protein coding gene Chr14:43983965-44007461 (-)
AKR/J ENSMUSG00220025893
protein coding gene Chr14:43311897-43335384 (-)
BALB/cJ ENSMUSG00180049500
protein coding gene Chr14:43607698-43631191 (-)
C3H/HeJ ENSMUSG00175047197
protein coding gene Chr14:45290085-45313576 (-)
C57BL/6NJ ENSMUSG00215045533
protein coding gene Chr14:43502485-43526066 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019282
protein coding gene Chr14:46372889-46397895 (-)
CAST/EiJ ENSTCUG00005048319
protein coding gene Chr14:45288014-45310943 (-)
CBA/J ENSMUSG00210035899
protein coding gene Chr14:43970592-43994083 (-)
DBA/2J ENSMUSG00185049957
protein coding gene Chr14:49029882-49053380 (-)
FVB/NJ ENSMUSG00205027445
protein coding gene Chr14:43367455-43390954 (-)
JF1/MsJ ENSUMUG00000035318
protein coding gene Chr14:60268849-60292435 (-)
LP/J ENSMUSG00230052451
protein coding gene Chr14:61125523-61149014 (-)
NOD/ShiLtJ ENSMUSG00190040979
protein coding gene Chr14:43728375-43751882 (-)
NZO/HlLtJ ENSMUSG00225048393
protein coding gene Chr14:51423649-51447142 (-)
PWK/PhJ ENSLUMG00010040859
protein coding gene Chr14:43193371-43216866 (-)
SPRET/EiJ ENSMSPG00010035681
protein coding gene Chr14:46590707-46615817 (-)
WSB/EiJ ENSIUOG00005035002
protein coding gene Chr14:43192498-43215992 (-)



Homology
more
  • Human Ortholog
    MYH6, myosin heavy chain 6
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYH6, myosin heavy chain 6
  • Synonyms
    alpha-MHC, ASD3, CMD1EE, CMH14, MYHC, MYHCA, SSS3
  • Links
    NCBI Gene ID: 4624
    UniProt: P13533

  • Chr Location
    14q11.2; chr14:23381576-23408945 (-)  GRCh38

Human Diseases
more
  • Diseases
    4 with Myh6 mouse models; 6 with human MYH6 associations

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 7 models
      
IDs
View 2 models
IDs
View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    7 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 8 alleles in 8 genetic backgrounds
    39 phenotypes from multigenic genotypes
    5 images
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with heart defects while heterozygotes show cardiac myofibrillar disarray, cardiac dysfunction and fibrosis. Mice heterozygous for different knock-in alleles may develop hypertrophic or dilated forms of cardiomyopathy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040752 Ensembl Gene Model | MGI Sequence Detail 25007 C57BL/6J ±  kb
    transcript ENSMUST00000081857 Ensembl | MGI Sequence Detail 6113 Not Applicable  
    polypeptide ENSMUSP00000080538 Ensembl | MGI Sequence Detail 1938 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 1
      cDNA 16
      Primer pair 27
      Other 13
      Antibodies 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12741, MGD-MRK-12743, MGI:2145563
    References
    more
    • Summaries
      All 346
      Developmental Gene Expression 160
      Diseases 9
      Gene Ontology 24
      Phenotypes 75
    • Earliest
      J:8079 Weydert A, et al., Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7183-7
    • Latest
      J:385419 Nakano H, et al., Maternal hyperglycemia disrupts cardiomyocyte maturation via aberrant nucleotide metabolism and suppression of AMPK signaling. Cell Rep. 2026 May 4;45(5):117321

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory