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Gria3 Gene Detail
Summary
  • Symbol
    Gria3
  • Name
    glutamate receptor, ionotropic, AMPA3 (alpha 3)
  • Synonyms
    2900064I19Rik, Glur-3, Glur3, GluR3, Gluralpha3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95810
    NCBI Gene: 53623
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:40489731-40767478 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 23.19 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3846 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95810
 protein coding gene ChrX:40489351-40767478 (+)
129S1/SvImJ ENSMUSG00200021602
 protein coding gene ChrX:24431440-24709368 (+)
A/J ENSMUSG00195024471
 protein coding gene ChrX:27074866-27352803 (+)
AKR/J ENSMUSG00220024576
 protein coding gene ChrX:24121003-24398944 (+)
BALB/cJ ENSMUSG00180011878
 protein coding gene ChrX:24850253-25128170 (+)
C3H/HeJ ENSMUSG00175022797
 protein coding gene ChrX:27835871-28113803 (+)
C57BL/6NJ ENSMUSG00215017849
 protein coding gene ChrX:24840609-25121107 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033022
 protein coding gene ChrX:34582547-34847256 (+)
CAST/EiJ ENSTCUG00005032358
 protein coding gene ChrX:26978426-27256474 (+)
CBA/J ENSMUSG00210032562
 protein coding gene ChrX:25131605-25409534 (+)
DBA/2J ENSMUSG00185023865
 protein coding gene ChrX:35837898-36115895 (+)
FVB/NJ ENSMUSG00205007022
 protein coding gene ChrX:23756686-24041306 (+)
JF1/MsJ ENSUMUG00000017961
 protein coding gene ChrX:54950749-55221026 (+)
LP/J ENSMUSG00230018173
 protein coding gene ChrX:42335381-42613263 (+)
NOD/ShiLtJ ENSMUSG00190020734
 protein coding gene ChrX:24305248-24583175 (+)
NZO/HlLtJ ENSMUSG00225039424
 protein coding gene ChrX:47536896-47814813 (+)
PWK/PhJ ENSLUMG00010033978
 protein coding gene ChrX:24677886-24947204 (+)
SPRET/EiJ ENSMSPG00010015416
 protein coding gene ChrX:26015855-26306701 (+)
WSB/EiJ ENSIUOG00005037121
 protein coding gene ChrX:25298721-25582605 (+)



Homology
more
  • Human Ortholog
    GRIA3, glutamate ionotropic receptor AMPA type subunit 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIA3, glutamate ionotropic receptor AMPA type subunit 3
  • Synonyms
    GluA3, GLUR3, GLUR-C, GLURC, GLUR-K3, iGluR3, MRX94, MRXSW
  • Links
    NCBI Gene ID: 2892
    UniProt: P42263

  • Chr Location
    Xq25; chrX:123184023-123490915 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GRIA3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 6 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for one allele display reduced fertility and enhanced long term potentiation. Male mice hemizygous for a second allele display decreased thermal nociception, resistance to drug induced seizures and a decreased startle reflex; and homozygous female mice have decreased body weight. A mutation associated with human impaired circadian rhythm changes the distribution of sleep and activity bouts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    106
  • cDNA Data
    42
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001986 Ensembl Gene Model | MGI Sequence Detail 277748 C57BL/6J ±  kb
    transcript ENSMUST00000115103 Ensembl | MGI Sequence Detail 3081 Not Applicable  
    polypeptide ENSMUSP00000110755 Ensembl | MGI Sequence Detail 888 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000008235 glutamate receptor 3
      (term hierarchy)
    • PDB
      3LSW, 3LSX
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q9Z2W9 8 sites, 11 N-linked glycans (4 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 1
      cDNA 44
      Primer pair 2
      Antibodies 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10142, MGD-MRK-10149, MGD-MRK-10248, MGI:1920286
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 37
      Gene Ontology 15
      Phenotypes 61
    • Earliest
      J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
    • Latest
      J:377482 Mitchell-Flack M, et al., The ionotropic AMPA receptor contributes to autoimmunity via altered regulatory T cell differentiation. iScience. 2026 Jan 16;29(1):114267
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory