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Egf Gene Detail
Summary
  • Symbol
    Egf
  • Name
    epidermal growth factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:95290
    NCBI Gene: 13645
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:129471223-129548971 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 58.50 cM
  • Mapping Data
    40 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2425 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95290
 protein coding gene Chr3:129471214-129548971 (-)
129S1/SvImJ ENSMUSG00200002908
 protein coding gene Chr3:126234255-126311922 (-)
A/J ENSMUSG00195007997
 protein coding gene Chr3:126358735-126436409 (-)
AKR/J ENSMUSG00220021362
 protein coding gene Chr3:124790452-124868127 (-)
BALB/cJ ENSMUSG00180003659
 protein coding gene Chr3:126287424-126365099 (-)
C3H/HeJ ENSMUSG00175013465
 protein coding gene Chr3:125853604-125931463 (-)
C57BL/6NJ ENSMUSG00215019583
 protein coding gene Chr3:126620491-126698251 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025624
 protein coding gene Chr3:123270021-123349436 (-)
CAST/EiJ ENSTCUG00005003507
 protein coding gene Chr3:126934716-127012137 (-)
CBA/J ENSMUSG00210003414
 protein coding gene Chr3:126462406-126540116 (-)
DBA/2J ENSMUSG00185026168
 protein coding gene Chr3:127075295-127153147 (-)
FVB/NJ ENSMUSG00205018450
 protein coding gene Chr3:125403717-125481394 (-)
JF1/MsJ ENSUMUG00000016456
 protein coding gene Chr3:125808584-125887342 (-)
LP/J ENSMUSG00230003760
 protein coding gene Chr3:129054582-129132247 (-)
NOD/ShiLtJ ENSMUSG00190001234
 protein coding gene Chr3:127468282-127545945 (-)
NZO/HlLtJ ENSMUSG00225003015
 protein coding gene Chr3:131510039-131587878 (-)
PWK/PhJ ENSLUMG00010014715
 protein coding gene Chr3:125831850-125910803 (-)
SPRET/EiJ ENSMSPG00010012682
 protein coding gene Chr3:126804869-126885780 (-)
WSB/EiJ ENSIUOG00005016689
 protein coding gene Chr3:126585495-126663615 (-)



Homology
more
  • Human Ortholog
    EGF, epidermal growth factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EGF, epidermal growth factor
  • Synonyms
    HOMG4, URG
  • Links
    NCBI Gene ID: 1950
    UniProt: P01133

  • Chr Location
    4q25; chr4:109912883-110013766 (+)  GRCh38
Human Diseases
more
  • Diseases
    11 with human EGF associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    21 phenotype references
Null mutants have normal phenotype. Females triply null, for this locus and the amphiregulin and transforming growth factor alpha genes, are unable to nurse due to impaired mammary gland development and show mild integument and digestive system anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    121
  • cDNA Data
    140
  • Literature Summary
    51
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13645 NCBI Gene Model | MGI Sequence Detail 77749 C57BL/6J ±  kb
transcript NM_010113 RefSeq | MGI Sequence Detail 4773 ZRU/MplStud  
polypeptide P01132 UniProt | EBI | MGI Sequence Detail 1217 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 163
    Genomic 3
    cDNA 143
    Primer pair 15
    Other 2
    Antibodies 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-9315, MGI:2139798
References
more
  • Summaries
    All 276
    Developmental Gene Expression 51
    Diseases 1
    Gene Ontology 39
    Phenotypes 21
  • Earliest
    J:70074 Nexo E, et al., Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proc Natl Acad Sci U S A. 1980 May;77(5):2782-5
  • Latest
    J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory