About   Help   FAQ
Ca2 Gene Detail
Summary
  • Symbol
    Ca2
  • Name
    carbonic anhydrase 2
  • Synonyms
    CA II, CAII, Car-2, Car2, Ltw-5, Lvtw-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88269
    NCBI Gene: 12349
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:14951333-14965830 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 3.23 cM
  • Mapping Data
    43 experiments
Strain
Comparison
more
  • SNPs within 2kb
    536 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88269
 protein coding gene Chr3:14951329-14965830 (+)
129S1/SvImJ ENSMUSG00200018206
 protein coding gene Chr3:11693756-11708253 (+)
A/J ENSMUSG00195015257
 protein coding gene Chr3:11976329-11990359 (+)
AKR/J ENSMUSG00220008740
 protein coding gene Chr3:12030963-12045460 (+)
BALB/cJ ENSMUSG00180000974
 protein coding gene Chr3:11997222-12011255 (+)
C3H/HeJ ENSMUSG00175002982
 protein coding gene Chr3:11999559-12013589 (+)
C57BL/6NJ ENSMUSG00215001231
 protein coding gene Chr3:11993038-12007536 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024858
 protein coding gene Chr3:10278079-10292220 (+)
CAST/EiJ ENSTCUG00005023652
 protein coding gene Chr3:11921839-11935875 (+)
CBA/J ENSMUSG00210001607
 protein coding gene Chr3:11968444-11982474 (+)
DBA/2J ENSMUSG00185000601
 protein coding gene Chr3:11971214-11985246 (+)
FVB/NJ ENSMUSG00205002283
 protein coding gene Chr3:11699941-11713971 (+)
JF1/MsJ ENSUMUG00000018226
 protein coding gene Chr3:11796508-11810534 (+)
LP/J ENSMUSG00230004355
 protein coding gene Chr3:13895679-13910175 (+)
NOD/ShiLtJ ENSMUSG00190002074
 protein coding gene Chr3:12075922-12090417 (+)
NZO/HlLtJ ENSMUSG00225000702
 protein coding gene Chr3:16477886-16491912 (+)
PWK/PhJ ENSLUMG00010003049
 protein coding gene Chr3:11934007-11948058 (+)
SPRET/EiJ ENSMSPG00010001815
 protein coding gene Chr3:11755310-11768842 (+)
WSB/EiJ ENSIUOG00005001383
 protein coding gene Chr3:12051153-12065645 (+)



Homology
more
  • Human Ortholog
    CA2, carbonic anhydrase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CA2, carbonic anhydrase 2
  • Synonyms
    CAC, CA-II, CAII, Car2, HEL-76, HEL-S-282
  • Links
    NCBI Gene ID: 760
    UniProt: P00918

  • Chr Location
    8q21.2; chr8:85463968-85481493 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ca2 mouse models; 10 with human CA2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are growth retarded, display renal tubular acidosis, but mutants have not been recovered that display osteopetrosis as found in human CA-II deficiency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1003
  • Tissues
    243
  • cDNA Data
    244
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027562 Ensembl Gene Model | MGI Sequence Detail 14498 C57BL/6J ±  kb
    transcript ENSMUST00000029078 Ensembl | MGI Sequence Detail 1788 Not Applicable  
    polypeptide ENSMUSP00000029078 Ensembl | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 258
      Genomic 5
      cDNA 245
      Primer pair 6
      Other 2
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11922, MGD-MRK-11945, MGD-MRK-1760, MGD-MRK-1763, MGI:2139632, MGI:8353809
    References
    more
    • Summaries
      All 171
      Developmental Gene Expression 41
      Diseases 2
      Gene Ontology 19
      Phenotypes 38
    • Earliest
      J:5671 Davisson MT, et al., Genes on chromosome 3 of the mouse. J Hered. 1976 May-Jun;67(3):155-6
    • Latest
      J:375094 Murillo-Rincon AP, et al., Positional programs in early murine facial development and their role in human facial shape variability. Nat Commun. 2025 Nov 18;16(1):10112
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory