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Chemically induced Allele Detail
Symbol: Car2n
Name: carbonic anhydrase 2; null
MGI ID: MGI:2135646
Synonyms: CAII-, CA(II)D, Car2-, Car-20, Car2N
Gene: Car2  Location: Chr3:14951333-14965830 bp, + strand  Genetic Position: Chr3, 3.23 cM
Alliance: Car2n page
Morphological changes in the stomach and intestine of Car2n/Car2n and Car9tm1Spas/Car9tm1Spas mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  DBA/2J
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
Mutation detailsThe result of ENU mutagenesis, the mutation at the Car2 locus is likely a nonsense or missense mutation. Molecular analysis shows that the mutant gene is not deleted but is transcribed. The CAR2 protein could not be detected by immunodiffusion analysis and Southern analysis indicates no detectable rearrangements or polymorphisms. (J:19268)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Car2 Mutation:  13 strains or lines available
Original:  J:19268 Lewis SE, et al., N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1962-6
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory