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Aldoa Gene Detail
Summary
  • Symbol
    Aldoa
  • Name
    aldolase A, fructose-bisphosphate
  • Synonyms
    Aldo1, Aldo-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:87994
    NCBI Gene: 11674
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126394406-126399537 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.25 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87994
 protein coding gene Chr7:126394406-126399923 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033000
 protein coding gene Chr7:131093581-131099540 (-)
A/J MGP_AJ_G0032983
 protein coding gene Chr7:127621196-127626715 (-)
AKR/J MGP_AKRJ_G0032915
 protein coding gene Chr7:130854762-130862106 (-)
BALB/cJ MGP_BALBcJ_G0032988
 protein coding gene Chr7:127282912-127288427 (-)
C3H/HeJ MGP_C3HHeJ_G0032698
 protein coding gene Chr7:130792427-130798499 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033494
 protein coding gene Chr7:136187991-136193487 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030466
 protein coding gene Chr7:128813691-128819206 (-)
CAST/EiJ MGP_CASTEiJ_G0032027
 protein coding gene Chr7:122579353-122584860 (-)
CBA/J MGP_CBAJ_G0032671
 protein coding gene Chr7:140771418-140779673 (-)
DBA/2J MGP_DBA2J_G0032823
 protein coding gene Chr7:125594767-125600378 (-)
FVB/NJ MGP_FVBNJ_G0032776
 protein coding gene Chr7:125443465-125448978 (-)
LP/J MGP_LPJ_G0032917
 protein coding gene Chr7:132563960-132569463 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032808
 protein coding gene Chr7:141955829-141962534 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033513
 protein coding gene Chr7:129861951-129867498 (-)
PWK/PhJ MGP_PWKPhJ_G0031734
 protein coding gene Chr7:118589865-118595626 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031580
 protein coding gene Chr7:116711657-116717182 (-)
WSB/EiJ MGP_WSBEiJ_G0032139
 protein coding gene Chr7:130841480-130846972 (-)



Homology
more
  • Human Ortholog
    ALDOA, aldolase, fructose-bisphosphate A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALDOA, aldolase, fructose-bisphosphate A
  • Synonyms
    ALDA, GSD12, HEL-S-87p
  • Links
    NCBI Gene ID: 226
    neXtProt AC: NX_P04075
    UniProt: P04075

  • Chr Location
    16p11.2; chr16:30064164-30070457 (+)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    299
  • Tissues
    200
  • cDNA Data
    1045
  • Literature Summary
    29
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11674 NCBI Gene Model | MGI Sequence Detail 5132 C57BL/6J ±  kb
transcript NM_001177307 RefSeq | MGI Sequence Detail 1595 C57BL/6  
polypeptide P05064 UniProt | EBI | MGI Sequence Detail 364 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1052
    Genomic 2
    cDNA 1045
    Primer pair 4
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-1276, MGD-MRK-1278
References
more
  • Summaries
    All 119
    Developmental Gene Expression 29
    Diseases 3
    Gene Ontology 16
    Phenotypes 45
  • Earliest
    J:21434 Paolella G, et al., Structure and expression of mouse aldolase genes. Brain-specific aldolase C amino acid sequence is closely related to aldolase A. Eur J Biochem. 1986 Apr 15;156(2):229-35
  • Latest
    J:342026 Hasegawa Y, et al., Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11.2 duplication. Nat Commun. 2023 Oct 25;14(1):6559
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory