Adamts17 MGI Mouse Gene Detail - MGI:3588195 - ADAM metallopeptidase with thrombospondin type 1 motif 17

Symbol

Adamts17
Name

ADAM metallopeptidase with thrombospondin type 1 motif 17
Synonyms

AU023434

Feature Type

protein coding gene
IDs

MGI:3588195
NCBI Gene: 233332
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:66489483-66802919 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 36.26 cM
Mapping Data

2 experiments

SNPs within 2kb

9841 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3588195	protein coding gene	Chr7:66487387-66802919 (+)
129S1/SvImJ	ENSMUSG00200010560	protein coding gene	Chr7:53198689-53512251 (+)
A/J	ENSMUSG00195012523	protein coding gene	Chr7:57621887-57935433 (+)
AKR/J	ENSMUSG00220019852	protein coding gene	Chr7:51123924-51437524 (+)
BALB/cJ	ENSMUSG00180004388	protein coding gene	Chr7:54326455-54646658 (+)
C3H/HeJ	ENSMUSG00175010850	protein coding gene	Chr7:55125702-55439258 (+)
C57BL/6NJ	ENSMUSG00215011194	protein coding gene	Chr7:54265765-54579317 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029846	protein coding gene	Chr7:69577649-69883114 (+)
CAST/EiJ	ENSTCUG00005011927	protein coding gene	Chr7:57804622-58126809 (+)
CBA/J	ENSMUSG00210019711	protein coding gene	Chr7:54964192-55277735 (+)
DBA/2J	ENSMUSG00185005763	protein coding gene	Chr7:59296296-59618337 (+)
FVB/NJ	ENSMUSG00205003750	protein coding gene	Chr7:54968134-55288310 (+)
JF1/MsJ	ENSUMUG00000007369	protein coding gene	Chr7:64042681-64364795 (+)
LP/J	ENSMUSG00230019007	protein coding gene	Chr7:65385240-65702364 (+)
NOD/ShiLtJ	ENSMUSG00190006844	protein coding gene	Chr7:55072412-55385992 (+)
NZO/HlLtJ	ENSMUSG00225015546	protein coding gene	Chr7:63663914-63977468 (+)
PWK/PhJ	ENSLUMG00010018277	protein coding gene	Chr7:53586960-53906688 (+)
SPRET/EiJ	ENSMSPG00010002806	protein coding gene	Chr7:53948015-54279505 (+)
WSB/EiJ	ENSIUOG00005004256	protein coding gene	Chr7:55503289-55851626 (+)

Human Ortholog

ADAMTS17, ADAM metallopeptidase with thrombospondin type 1 motif 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADAMTS17, ADAM metallopeptidase with thrombospondin type 1 motif 17
Synonyms

WMS4
Links

HGNC:17109

NCBI Gene ID: 170691

UniProt: Q8TE56
Chr Location

15q26.3; chr15:99971437-100342005 (-) GRCh38

MGI Vertebrate Homology

Adamts17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADAMTS17
Gene Tree

Adamts17

Diseases

1 with Adamts17 mouse models; 1 with human ADAMTS17 associations

Human Disease

Mouse Models

Weill-Marchesani syndrome

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

29 phenotypes from 3 alleles in 3 genetic backgrounds
27 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Adamts17
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

619
Tissues

16
cDNA Data

21
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adamts17

ZFIN adamts17

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All Sequences

59
RefSeq

10
UniProt

6
CCDS

CCDS21349.2

Ensembl

ENSMUSG00000058145 (Evidence)
NCBI Gene

233332

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058145	Ensembl Gene Model \| MGI Sequence Detail	313437	C57BL/6J	± kb
transcript	ENSMUST00000098382	Ensembl \| MGI Sequence Detail	6025	Not Applicable
polypeptide	ENSMUSP00000095984	Ensembl \| MGI Sequence Detail	1122	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000030471 a disintegrin and metalloproteinase with thrombospondin motifs 17

(term hierarchy)
InterPro Domains

IPR006586 ADAM, cysteine-rich domain

IPR013273 ADAMTS/ADAMTS-like

IPR045371 ADAMTS/ADAMTS-like, cysteine-rich domain 3

IPR010294 ADAMTS/ADAMTS-like, Spacer 1

IPR050439 ADAMTS and ADAMTS-like

IPR041645 ADAMTS, cysteine-rich domain 2

IPR056270 A disintegrin and metalloproteinase with thrombospondin motifs 17/19, C-terminal helical domain

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR002870 Peptidase M12B, propeptide

IPR010909 PLAC

IPR036383 Thrombospondin type-1 repeat superfamily

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR013087 Zinc finger C2H2-type

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All nucleic 23

cDNA 21

Primer pair 2

Antibodies 2

Microarray probesets 6

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MGI:3034316

Summaries

All 41

Developmental Gene Expression 7

Diseases 1

Gene Ontology 5

Phenotypes 14
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:373026 Taye N, et al., Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes. Life Sci Alliance. 2025 Dec;8(12)

TSS for Adamts17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67075	Chr7:66489474-66489498 (+)	3 bp
Tssr67076	Chr7:66489500-66489518 (+)	26 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24