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Vtcn1 Gene Detail
Summary
  • Symbol
    Vtcn1
  • Name
    V-set domain containing T cell activation inhibitor 1
  • Synonyms
    B7-H4, B7x
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039619
    NCBI Gene: 242122
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:100732775-100804238 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 43.78 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2299 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039619
 protein coding gene Chr3:100732775-100805555 (+)
129S1/SvImJ ENSMUSG00200044147
 protein coding gene Chr3:97337458-97408926 (+)
A/J ENSMUSG00195041121
 protein coding gene Chr3:97743006-97814488 (+)
AKR/J ENSMUSG00220040606
 protein coding gene Chr3:96103165-96174623 (+)
BALB/cJ ENSMUSG00180033259
 protein coding gene Chr3:97682632-97754094 (+)
C3H/HeJ ENSMUSG00175022216
 protein coding gene Chr3:97228890-97300346 (+)
C57BL/6NJ ENSMUSG00215024928
 protein coding gene Chr3:97994903-98066379 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025425
 protein coding gene Chr3:94942784-95014775 (+)
CAST/EiJ ENSTCUG00005018459
 protein coding gene Chr3:97945176-98024986 (+)
CBA/J ENSMUSG00210050935
 protein coding gene Chr3:97851090-97922534 (+)
DBA/2J ENSMUSG00185038397
 protein coding gene Chr3:98336278-98407747 (+)
FVB/NJ ENSMUSG00205014886
 protein coding gene Chr3:96914419-96985891 (+)
JF1/MsJ ENSUMUG00000046949
 protein coding gene Chr3:97046912-97119460 (+)
LP/J ENSMUSG00230044159
 protein coding gene Chr3:100266122-100337593 (+)
NOD/ShiLtJ ENSMUSG00190026210
 protein coding gene Chr3:98523721-98595193 (+)
NZO/HlLtJ ENSMUSG00225019349
 protein coding gene Chr3:102716075-102787535 (+)
PWK/PhJ ENSLUMG00010028056
 protein coding gene Chr3:97137290-97210328 (+)
SPRET/EiJ ENSMSPG00010045120
 protein coding gene Chr3:97387762-97454382 (+)
WSB/EiJ ENSIUOG00005030717
 protein coding gene Chr3:97870587-97942047 (+)



Homology
more
  • Human Ortholog
    VTCN1, V-set domain containing T cell activation inhibitor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VTCN1, V-set domain containing T cell activation inhibitor 1
  • Synonyms
    B7-H4, B7H4, B7h.5, B7S1, B7X, PRO1291, VCTN1
  • Links
    NCBI Gene ID: 79679
    UniProt: Q7Z7D3

  • Chr Location
    1p13.1-p12; chr1:117143587-117210960 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    9 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for this mutation display stronger Th1 responses upon parasitic infection by L. major including reduced footpad swelling and lower parasite burden compared to controls. Responses to other Th1-driven immune responses are normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    612
  • Tissues
    15
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051076 Ensembl Gene Model | MGI Sequence Detail 71464 C57BL/6J ±  kb
    transcript ENSMUST00000054791 Ensembl | MGI Sequence Detail 2622 Not Applicable  
    polypeptide ENSMUSP00000057721 Ensembl | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 12
      Phenotypes 27
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:352035 Yu J, et al., Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance. Cell. 2024 Jun 28;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory