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Akap5 Gene Detail
Summary
  • Symbol
    Akap5
  • Name
    A kinase anchor protein 5
  • Synonyms
    3526401B18Rik, AKAP150, LOC238276
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685104
    NCBI Gene: 238276
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:76371665-76380927 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 33.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685104
 protein coding gene Chr12:76371652-76380927 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019855
 protein coding gene Chr12:76423798-76432984 (+)
A/J MGP_AJ_G0019813
 protein coding gene Chr12:73528354-73537458 (+)
AKR/J MGP_AKRJ_G0019788
 protein coding gene Chr12:75750828-75758255 (+)
BALB/cJ MGP_BALBcJ_G0019792
 protein coding gene Chr12:73999090-74008273 (+)
C3H/HeJ MGP_C3HHeJ_G0019598
 protein coding gene Chr12:76215593-76224778 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020244
 protein coding gene Chr12:78773258-78782499 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017862
 protein coding gene Chr12:70863876-70873418 (+)
CAST/EiJ MGP_CASTEiJ_G0019147
 protein coding gene Chr12:70878188-70882622 (-)
CBA/J MGP_CBAJ_G0019568
 protein coding gene Chr12:81816782-81827425 (+)
DBA/2J MGP_DBA2J_G0019684
 protein coding gene Chr12:73378802-73387973 (+)
FVB/NJ MGP_FVBNJ_G0019671
 protein coding gene Chr12:72223533-72232500 (+)
LP/J MGP_LPJ_G0019756
 protein coding gene Chr12:76405327-76414369 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019710
 protein coding gene Chr12:84848408-84858131 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020280
 protein coding gene Chr12:75228015-75237809 (+)
PWK/PhJ MGP_PWKPhJ_G0018915
 protein coding gene Chr12:67750916-67760295 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018709
 protein coding gene Chr12:69741024-69750551 (+)
WSB/EiJ MGP_WSBEiJ_G0019201
 protein coding gene Chr12:75842333-75851570 (+)



Homology
more
  • Human Ortholog
    AKAP5, A-kinase anchoring protein 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKAP5, A-kinase anchoring protein 5
  • Synonyms
    AKAP75, AKAP79, H21
  • Links
    NCBI Gene ID: 9495
    neXtProt AC: NX_P24588
    UniProt: P24588

  • Chr Location
    14q23.3; chr14:64465499-64474503 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 5 alleles in 7 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced long term potentiation, improved glucose handling and heightened insulin sensitivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    18
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021057 Ensembl Gene Model | MGI Sequence Detail 9263 C57BL/6J ±  kb
    transcript ENSMUST00000095610 Ensembl | MGI Sequence Detail 6687 Not Applicable  
    polypeptide ENSMUSP00000093270 Ensembl | MGI Sequence Detail 752 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1918024, MGI:2145066
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 1
      Gene Ontology 18
      Phenotypes 43
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:332719 Sanderson JL, et al., beta-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca(2+)-permeable AMPA receptors. Cell Rep. 2021 Oct 5;37(1):109786
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory