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Zdhhc19 Gene Detail
Summary
  • Symbol
    Zdhhc19
  • Name
    zinc finger, DHHC domain containing 19
  • Synonyms
    LOC245308, MGC:58833
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682948
    NCBI Gene: 245308
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:32315059-32326032 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 22.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682948
 protein coding gene Chr16:32315059-32380784 (+)
129S1/SvImJ ENSMUSG00200035633
 protein coding gene Chr16:29336138-29347092 (+)
A/J ENSMUSG00195027713
 protein coding gene Chr16:28875281-28886439 (+)
AKR/J ENSMUSG00220031462
 protein coding gene Chr16:29167524-29178686 (+)
BALB/cJ ENSMUSG00180026421
 protein coding gene Chr16:29091151-29102308 (+)
C3H/HeJ ENSMUSG00175036625
 protein coding gene Chr16:29235850-29247005 (+)
C57BL/6NJ ENSMUSG00215015748
 protein coding gene Chr16:29120943-29131895 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020675
 protein coding gene Chr16:29506545-29576044 (+)
CAST/EiJ ENSTCUG00005035696
 protein coding gene Chr16:29507848-29518820 (+)
CBA/J ENSMUSG00210032175
 protein coding gene Chr16:29277851-29289006 (+)
DBA/2J ENSMUSG00185017664
 protein coding gene Chr16:29193329-29204484 (+)
FVB/NJ ENSMUSG00205018999
 protein coding gene Chr16:29206793-29217951 (+)
JF1/MsJ ENSUMUG00000019990
 protein coding gene Chr16:29401040-29412085 (+)
LP/J ENSMUSG00230028846
 protein coding gene Chr16:31762072-31773226 (+)
NOD/ShiLtJ ENSMUSG00190029795
 protein coding gene Chr16:29382730-29393890 (+)
NZO/HlLtJ ENSMUSG00225037751
 protein coding gene Chr16:34995135-35006310 (+)
PWK/PhJ ENSLUMG00010029085
 protein coding gene Chr16:29195796-29206771 (+)
SPRET/EiJ ENSMSPG00010018320
 protein coding gene Chr16:29187813-29199026 (+)
WSB/EiJ ENSIUOG00005031334
 protein coding gene Chr16:29362608-29373577 (+)



Homology
more
  • Human Ortholog
    ZDHHC19, zDHHC palmitoyltransferase 19
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZDHHC19, zDHHC palmitoyltransferase 19
  • Synonyms
    DHHC19
  • Links
    NCBI Gene ID: 131540
    UniProt: Q8WVZ1

  • Chr Location
    3q29; chr3:196197452-196211437 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations of this gene result in male infertility associated with abnormal sperm head and flagellum morphology and asthenozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 245308 NCBI Gene Model | MGI Sequence Detail 10974 C57BL/6J ±  kb
    transcript NM_199309 RefSeq | MGI Sequence Detail 1310 C57BL/6  
    polypeptide Q810M5 UniProt | EBI | MGI Sequence Detail 347 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685462
    References
    more
    • Summaries
      All 44
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:91257 Gray PA, et al., Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
    • Latest
      J:366950 Kaneda Y, et al., TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice. Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2417943122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory