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Opalin Gene Detail
Summary
  • Symbol
    Opalin
  • Name
    oligodendrocytic myelin paranodal and inner loop protein
  • Synonyms
    Tmem10, Tmp10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2657025
    NCBI Gene: 226115
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:41050398-41065552 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 34.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2657025
 protein coding gene Chr19:41050149-41065552 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025119
 protein coding gene Chr19:40321782-40337796 (-)
A/J MGP_AJ_G0025096
 protein coding gene Chr19:38384108-38398907 (-)
AKR/J MGP_AKRJ_G0025064
 protein coding gene Chr19:39650416-39666479 (-)
BALB/cJ MGP_BALBcJ_G0025090
 protein coding gene Chr19:38434776-38449445 (-)
C3H/HeJ MGP_C3HHeJ_G0024850
 protein coding gene Chr19:39792882-39808066 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025534
 protein coding gene Chr19:41401548-41417015 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022947
 protein coding gene Chr19:37747601-37760912 (-)
CAST/EiJ MGP_CASTEiJ_G0024315
 protein coding gene Chr19:39427291-39443928 (-)
CBA/J MGP_CBAJ_G0024830
 protein coding gene Chr19:43414116-43432097 (-)
DBA/2J MGP_DBA2J_G0024962
 protein coding gene Chr19:38246160-38260745 (-)
FVB/NJ MGP_FVBNJ_G0024923
 protein coding gene Chr19:38000883-38015297 (-)
LP/J MGP_LPJ_G0025048
 protein coding gene Chr19:40338361-40353415 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024954
 protein coding gene Chr19:43072797-43092498 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025591
 protein coding gene Chr19:39677363-39691710 (-)
PWK/PhJ MGP_PWKPhJ_G0024065
 protein coding gene Chr19:38094511-38110103 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023868
 protein coding gene Chr19:38417831-38432878 (-)
WSB/EiJ MGP_WSBEiJ_G0024385
 protein coding gene Chr19:39842943-39860405 (-)



Homology
more
  • Human Ortholog
    OPALIN, oligodendrocytic myelin paranodal and inner loop protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OPALIN, oligodendrocytic myelin paranodal and inner loop protein
  • Synonyms
    HTMP10, TMEM10, TMP10
  • Links
    NCBI Gene ID: 93377
    neXtProt AC: NX_Q96PE5
    UniProt: Q96PE5

  • Chr Location
    10q24.1; chr10:96343221-96359365 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show increased exploratory activity in a novel environment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    37
  • cDNA Data
    6
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 226115 NCBI Gene Model | MGI Sequence Detail 15155 C57BL/6J ±  kb
transcript NM_153520 RefSeq | MGI Sequence Detail 2353 C57BL/6  
polypeptide Q7M750 UniProt | EBI | MGI Sequence Detail 143 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 6
    Primer pair 3

    Microarray probesets 1
References
more
  • Summaries
    All 30
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:74484 Nobile C, et al., Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia. Gene. 2002 Jan 9;282(1-2):87-94
  • Latest
    J:320720 Yu Z, et al., GATOR2 complex-mediated amino acid signaling regulates brain myelination. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2110917119
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory