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Upf2 Gene Detail
Summary
  • Symbol
    Upf2
  • Name
    UPF2 regulator of nonsense transcripts homolog (yeast)
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449307
    NCBI Gene: 326622
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:5956280-6061514 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 3.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2643 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449307
 protein coding gene Chr2:5956218-6061514 (+)
129S1/SvImJ ENSMUSG00200028087
 protein coding gene Chr2:2815522-2920772 (+)
A/J ENSMUSG00195015429
 protein coding gene Chr2:2933566-3038815 (+)
AKR/J ENSMUSG00220005088
 protein coding gene Chr2:2925050-3030291 (+)
BALB/cJ ENSMUSG00180028556
 protein coding gene Chr2:3027351-3132691 (+)
C3H/HeJ ENSMUSG00175016495
 protein coding gene Chr2:2916239-3021489 (+)
C57BL/6NJ ENSMUSG00215008965
 protein coding gene Chr2:3048152-3153388 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023157
 protein coding gene Chr2:2749765-2855383 (+)
CAST/EiJ ENSTCUG00005004397
 protein coding gene Chr2:2908395-3017426 (+)
CBA/J ENSMUSG00210026493
 protein coding gene Chr2:2956554-3061806 (+)
DBA/2J ENSMUSG00185012089
 protein coding gene Chr2:2916068-3021317 (+)
FVB/NJ ENSMUSG00205018529
 protein coding gene Chr2:2897938-3003227 (+)
JF1/MsJ ENSUMUG00000001543
 protein coding gene Chr2:2897299-3000109 (+)
LP/J ENSMUSG00230002220
 protein coding gene Chr2:4863442-4968691 (+)
NOD/ShiLtJ ENSMUSG00190005469
 protein coding gene Chr2:2922534-3027775 (+)
NZO/HlLtJ ENSMUSG00225001695
 protein coding gene Chr2:12599573-12704803 (+)
PWK/PhJ ENSLUMG00010027633
 protein coding gene Chr2:2951165-3053988 (+)
SPRET/EiJ ENSMSPG00010025920
 protein coding gene Chr2:2941026-3045310 (+)
WSB/EiJ ENSIUOG00005021841
 protein coding gene Chr2:2934560-3039380 (+)



Homology
more
  • Human Ortholog
    UPF2, UPF2 regulator of nonsense mediated mRNA decay
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UPF2, UPF2 regulator of nonsense mediated mRNA decay
  • Synonyms
    HUPF2, RENT2, smg-3
  • Links
    NCBI Gene ID: 26019
    UniProt: Q9HAU5

  • Chr Location
    10p14; chr10:11920020-12043170 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    632
  • Tissues
    18
  • cDNA Data
    66
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043241 Ensembl Gene Model | MGI Sequence Detail 105235 C57BL/6J ±  kb
    transcript ENSMUST00000060092 Ensembl | MGI Sequence Detail 5174 Not Applicable  
    polypeptide ENSMUSP00000058375 Ensembl | MGI Sequence Detail 1269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 66
      Primer pair 1
      Antibodies 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 25
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:382739 Lin L, et al., Nonsense-mediated mRNA decay orchestrates neuronal migration and cortical lamination while modulating Reelin and ciliary gene regulatory networks. Cell Rep. 2026 Mar 24;45(3):117027
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory