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Apol8 Gene Detail
Summary
  • Symbol
    Apol8
  • Name
    apolipoprotein L 8
  • Synonyms
    9830006J20Rik, Apol2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444921
    NCBI Gene: 239552
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:77631998-77641203 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 36.79 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    415 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444921
 protein coding gene Chr15:77629309-77641306 (-)
129S1/SvImJ ENSMUSG00200052529
 protein coding gene Chr15:74747301-74756504 (-)
A/J ENSMUSG00195044425
 protein coding gene Chr15:74689549-74698754 (-)
AKR/J ENSMUSG00220049798
 protein coding gene Chr15:74733093-74742296 (-)
BALB/cJ ENSMUSG00180053052
 protein coding gene Chr15:74566628-74575827 (-)
C3H/HeJ ENSMUSG00175051980
 protein coding gene Chr15:74878022-74887225 (-)
C57BL/6NJ ENSMUSG00215047949
 protein coding gene Chr15:74639210-74648411 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019969
 protein coding gene Chr15:71756271-71764636 (-)
CAST/EiJ ENSTCUG00005042001
 protein coding gene Chr15:74189979-74199390 (-)
CBA/J ENSMUSG00210044470
 protein coding gene Chr15:74653230-74662429 (-)
DBA/2J ENSMUSG00185041432
 protein coding gene Chr15:74662638-74671843 (-)
FVB/NJ ENSMUSG00205039030
 protein coding gene Chr15:74382740-74391950 (-)
JF1/MsJ ENSUMUG00000045597
 protein coding gene Chr15:74232874-74242079 (-)
LP/J ENSMUSG00230052488
 protein coding gene Chr15:77995851-78005052 (-)
NOD/ShiLtJ ENSMUSG00190051277
 protein coding gene Chr15:74674263-74683317 (-)
NZO/HlLtJ ENSMUSG00225051745
 protein coding gene Chr15:78325196-78334246 (-)
PWK/PhJ ENSLUMG00010045378
 protein coding gene Chr15:74464037-74473381 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005048415
 protein coding gene Chr15:74719804-74729204 (-)



Homology
more
  • Human Ortholog
    APOL1, apolipoprotein L1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOL1, apolipoprotein L1
  • Synonyms
    APO-L, APOL, APOL-I, FSGS4
  • Links
    NCBI Gene ID: 8542
    UniProt: O14791

  • Chr Location
    22q12.3; chr22:36253071-36267530 (+)  GRCh38
  • Human Ortholog
    APOL2, apolipoprotein L2
  • Synonyms
    APOL-II
  • Links
    NCBI Gene ID: 23780
    UniProt: Q9BQE5

  • Chr Location
    22q12.3; chr22:36226209-36239954 (-)  GRCh38
  • Human Ortholog
    APOL3, apolipoprotein L3
  • Synonyms
    apoL-III, APOLIII, CG12_1, CG121
  • Links
    NCBI Gene ID: 80833
    UniProt: O95236

  • Chr Location
    22q12.3; chr22:36139792-36166177 (-)  GRCh38
  • Human Ortholog
    APOL4, apolipoprotein L4
  • Synonyms
    APOL-IV, APOLIV
  • Links
    NCBI Gene ID: 80832
    UniProt: Q9BPW4

  • Chr Location
    22q12.3; chr22:36189124-36204840 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human APOL2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    621
  • Tissues
    1
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056656 Ensembl Gene Model | MGI Sequence Detail 9206 C57BL/6J ±  kb
transcript ENSMUST00000070911 Ensembl | MGI Sequence Detail 2801 Not Applicable  
polypeptide ENSMUSP00000064237 Ensembl | MGI Sequence Detail 339 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR008405 Apolipoprotein L
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 50
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 29
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory