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Dgki Gene Detail
Summary
  • Symbol
    Dgki
  • Name
    diacylglycerol kinase, iota
  • Synonyms
    C130010K08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443430
    NCBI Gene: 320127
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:36822957-37277119 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 15.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2652 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443430
 protein coding gene Chr6:36814316-37281034 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030575
 protein coding gene Chr6:35027037-35503146 (-)
A/J MGP_AJ_G0030548
 protein coding gene Chr6:33529387-33991074 (-)
AKR/J MGP_AKRJ_G0030475
 protein coding gene Chr6:34602837-35079581 (-)
BALB/cJ MGP_BALBcJ_G0030558
 protein coding gene Chr6:33718771-34177908 (-)
C3H/HeJ MGP_C3HHeJ_G0030271
 protein coding gene Chr6:34616096-35085906 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031012
 protein coding gene Chr6:35911136-36405598 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028224
 protein coding gene Chr6:31462717-31904103 (-)
CAST/EiJ MGP_CASTEiJ_G0029673
 protein coding gene Chr6:34434837-34917350 (-)
CBA/J MGP_CBAJ_G0030249
 protein coding gene Chr6:37295611-37797366 (-)
DBA/2J MGP_DBA2J_G0030393
 protein coding gene Chr6:33367524-33824177 (-)
FVB/NJ MGP_FVBNJ_G0030347
 protein coding gene Chr6:33156136-33613976 (-)
LP/J MGP_LPJ_G0030480
 protein coding gene Chr6:35137917-35597930 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030383
 protein coding gene Chr6:39711234-40198521 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031042
 protein coding gene Chr6:34511193-34985048 (-)
PWK/PhJ MGP_PWKPhJ_G0029387
 protein coding gene Chr6:32969601-33456027 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029223
 protein coding gene Chr6:34174794-34674904 (-)
WSB/EiJ MGP_WSBEiJ_G0029749
 protein coding gene Chr6:34453365-34934343 (-)



Homology
more
  • Human Ortholog
    DGKI, diacylglycerol kinase iota
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGKI, diacylglycerol kinase iota
  • Synonyms
    DGK-IOTA
  • Links
    NCBI Gene ID: 9162
    neXtProt AC: NX_O75912
    UniProt: O75912

  • Chr Location
    7q33; chr7:137381037-137847092 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele appear normal and do not develop tumors after wound induction or exposure to PMA. Mice homozygous for a different knock-out allele show increased body fat mass and percent body fat/body weight, decreased bone mineral density and increased plasma glycerol level.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    98
  • cDNA Data
    6
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038665 Ensembl Gene Model | MGI Sequence Detail 454163 C57BL/6J ±  kb
    transcript ENSMUST00000101532 Ensembl | MGI Sequence Detail 4596 Not Applicable  
    polypeptide ENSMUSP00000099071 Ensembl | MGI Sequence Detail 1071 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000006448 diacylglycerol kinase iota
      (term hierarchy)
    • EC
      2.7.1.107
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR037607 Diacylglycerol kinase
      IPR000756 Diacylglycerol kinase, accessory domain
      IPR001206 Diacylglycerol kinase, catalytic domain
      IPR047486 Diacylglycerol kinase iota, first protein kinase C conserved region 1
      IPR047487 Diacylglycerol kinase iota, second protein kinase C conserved region 1
      IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
      IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:325758 Bartsch VB, et al., Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice. Genes Brain Behav. 2020 Mar;19(3):e12570
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory