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Elmo1 Gene Detail
Summary
  • Symbol
    Elmo1
  • Name
    engulfment and cell motility 1
  • Synonyms
    6330578D22Rik, C230095H21Rik, CED-12
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153044
    NCBI Gene: 140580
  • Alliance
    genome feature page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:20274766-20792523 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 7.21 cM, cytoband A3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16821 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153044
 protein coding gene Chr13:20274677-20792523 (+)
129S1/SvImJ ENSMUSG00200012512
 protein coding gene Chr13:17630311-18061334 (+)
A/J ENSMUSG00195035554
 protein coding gene Chr13:16719951-17145507 (+)
AKR/J ENSMUSG00220026403
 protein coding gene Chr13:16635005-17059364 (+)
BALB/cJ ENSMUSG00180033033
 protein coding gene Chr13:17080536-17506076 (+)
C3H/HeJ ENSMUSG00175029732
 protein coding gene Chr13:17173814-17603410 (+)
C57BL/6NJ ENSMUSG00215019025
 protein coding gene Chr13:17126202-17549516 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018258
 protein coding gene Chr13:15401292-15910656 (+)
CAST/EiJ ENSTCUG00005013062
 protein coding gene Chr13:17207062-17630358 (+)
CBA/J ENSMUSG00210030381
 protein coding gene Chr13:17028426-17457970 (+)
DBA/2J ENSMUSG00185013051
 protein coding gene Chr13:17729739-18159346 (+)
FVB/NJ ENSMUSG00205023226
 protein coding gene Chr13:16876261-17325526 (+)
JF1/MsJ ENSUMUG00000018579
 protein coding gene Chr13:17461079-17881352 (+)
LP/J ENSMUSG00230033673
 protein coding gene Chr13:27136905-27561210 (+)
NOD/ShiLtJ ENSMUSG00190021364
 protein coding gene Chr13:16994226-17420529 (+)
NZO/HlLtJ ENSMUSG00225044705
 protein coding gene Chr13:20889077-21312366 (+)
PWK/PhJ ENSLUMG00010026902
 protein coding gene Chr13:16454680-16873064 (+)
SPRET/EiJ ENSMSPG00010016613
 protein coding gene Chr13:16055901-16585889 (+)
WSB/EiJ ENSIUOG00005030592
 protein coding gene Chr13:16360349-16796097 (+)



Homology
more
  • Human Ortholog
    ELMO1, engulfment and cell motility 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELMO1, engulfment and cell motility 1
  • Synonyms
    CED-12, CED12, ELMO-1
  • Links
    NCBI Gene ID: 9844
    UniProt: Q92556

  • Chr Location
    7p14.2-p14.1; chr7:36852906-37449326 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 7 alleles in 7 genetic backgrounds
    9 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired Sertoli cell phagocytosis of apoptotic male germ cells. Mice homozygous for an ENU-induced allele exhibit decreased CD4+ T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    971
  • Tissues
    153
  • cDNA Data
    53
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041112 Ensembl Gene Model | MGI Sequence Detail 517758 C57BL/6J ±  kb
    transcript ENSMUST00000072519 Ensembl | MGI Sequence Detail 5464 Not Applicable  
    polypeptide ENSMUSP00000072334 Ensembl | MGI Sequence Detail 727 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 53
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145189, MGI:2444821
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 35
    • Earliest
      J:71411 Arkell RM, et al., Genetic, physical, and phenotypic characterization of the Del(13)Svea36H mouse. Mamm Genome. 2001 Sep;12(9):687-94
    • Latest
      J:367496 Suresh A, et al., ELMO2 is an essential regulator of carotid artery development. Nat Commun. 2025 Jun 2;16(1):5108
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory