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Samd4 Gene Detail
Summary
  • Symbol
    Samd4
  • Name
    sterile alpha motif domain containing 4
  • Synonyms
    1700024G08Rik, 1700111L17Rik, 4933436G17Rik, Smaug, sunk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921730
    NCBI Gene: 74480
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:47120414-47343274 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 24.41 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5856 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921730
 protein coding gene Chr14:47120311-47343274 (+)
129S1/SvImJ ENSMUSG00200015199
 protein coding gene Chr14:35935437-36159344 (+)
A/J ENSMUSG00195020071
 protein coding gene Chr14:36141073-36365003 (+)
AKR/J ENSMUSG00220030081
 protein coding gene Chr14:35515997-35739953 (+)
BALB/cJ ENSMUSG00180035416
 protein coding gene Chr14:35744722-35973863 (+)
C3H/HeJ ENSMUSG00175024755
 protein coding gene Chr14:37430431-37654341 (+)
C57BL/6NJ ENSMUSG00215023583
 protein coding gene Chr14:36140500-36363672 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019161
 protein coding gene Chr14:38730492-38954410 (+)
CAST/EiJ ENSTCUG00005009441
 protein coding gene Chr14:37930354-38152574 (+)
CBA/J ENSMUSG00210038132
 protein coding gene Chr14:36075677-36299563 (+)
DBA/2J ENSMUSG00185051345
 protein coding gene Chr14:40864161-41089672 (+)
FVB/NJ ENSMUSG00205022714
 protein coding gene Chr14:35295863-35520656 (+)
JF1/MsJ ENSUMUG00000040469
 protein coding gene Chr14:52916205-53139455 (+)
LP/J ENSMUSG00230018057
 protein coding gene Chr14:53125340-53348466 (+)
NOD/ShiLtJ ENSMUSG00190031775
 protein coding gene Chr14:35766621-35991383 (+)
NZO/HlLtJ ENSMUSG00225047945
 protein coding gene Chr14:43372079-43596827 (+)
PWK/PhJ ENSLUMG00010029931
 protein coding gene Chr14:35363325-35586996 (+)
SPRET/EiJ ENSMSPG00010002988
 protein coding gene Chr14:38690297-38909253 (+)
WSB/EiJ ENSIUOG00005037979
 protein coding gene Chr14:35642324-35867754 (+)



Homology
more
  • Human Ortholog
    SAMD4A, sterile alpha motif domain containing 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAMD4A, sterile alpha motif domain containing 4A
  • Synonyms
    SAMD4, SMAUG, SMAUG1, SMG, SMGA
  • Links
    NCBI Gene ID: 23034
    UniProt: Q9UPU9

  • Chr Location
    14q22.2; chr14:54565316-54793315 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 2 alleles in 2 genetic backgrounds
    4 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit leaness, myopathy and altered glucose metabolism. Mice homozygous for a spontaneous mutation exhibit kyphosis, abnormal gait, and decreased cortical bone thickness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    608
  • Tissues
    9
  • cDNA Data
    17
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74480 NCBI Gene Model | MGI Sequence Detail 222861 C57BL/6J ±  kb
    transcript NM_001037221 RefSeq | MGI Sequence Detail 7120 C57BL/6  
    polypeptide Q8CBY1 UniProt | EBI | MGI Sequence Detail 711 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916635, MGI:1925725, MGI:3624555
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory