About   Help   FAQ
Clec16a Gene Detail
Summary
  • Symbol
    Clec16a
  • Name
    C-type lectin domain family 16, member A
  • Synonyms
    4932416N17Rik, curt, mKIAA0350
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921624
    NCBI Gene: 74374
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:10363203-10562742 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 5.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1059 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921624
 protein coding gene Chr16:10363173-10562742 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022510
 protein coding gene Chr16:7353500-7567101 (+)
A/J MGP_AJ_G0022472
 protein coding gene Chr16:6952968-7154871 (+)
AKR/J MGP_AKRJ_G0022448
 protein coding gene Chr16:7272437-7475174 (+)
BALB/cJ MGP_BALBcJ_G0022476
 protein coding gene Chr16:7085737-7285153 (+)
C3H/HeJ MGP_C3HHeJ_G0022243
 protein coding gene Chr16:7348776-7557750 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022925
 protein coding gene Chr16:7505133-7719755 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020446
 protein coding gene Chr16:7094325-7300016 (+)
CAST/EiJ MGP_CASTEiJ_G0021770
 protein coding gene Chr16:7367577-7577401 (+)
CBA/J MGP_CBAJ_G0022212
 protein coding gene Chr16:7831312-8056279 (+)
DBA/2J MGP_DBA2J_G0022343
 protein coding gene Chr16:6959278-7156866 (+)
FVB/NJ MGP_FVBNJ_G0022319
 protein coding gene Chr16:6942463-7139127 (+)
LP/J MGP_LPJ_G0022411
 protein coding gene Chr16:7311995-7521472 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022341
 protein coding gene Chr16:7569720-7777655 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022938
 protein coding gene Chr16:7219483-7424078 (+)
PWK/PhJ MGP_PWKPhJ_G0021510
 protein coding gene Chr16:7163696-7366028 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021340
 protein coding gene Chr16:7283832-7485543 (+)
WSB/EiJ MGP_WSBEiJ_G0021818
 protein coding gene Chr16:7294892-7501720 (+)



Homology
more
  • Human Ortholog
    CLEC16A, C-type lectin domain containing 16A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLEC16A, C-type lectin domain containing 16A
  • Synonyms
    Gop-1, KIAA0350
  • Links
    NCBI Gene ID: 23274
    neXtProt AC: NX_Q2KHT3
    UniProt: Q2KHT3

  • Chr Location
    16p13.13; chr16:10944539-11182186 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Clec16a mouse models; 4 with human CLEC16A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 5 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation have a curved tail, small body size, squinting eyes, crooked digits that curve outward, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    54
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068663 Ensembl Gene Model | MGI Sequence Detail 199540 C57BL/6J ±  kb
    transcript ENSMUST00000115824 Ensembl | MGI Sequence Detail 6244 Not Applicable  
    polypeptide ENSMUSP00000111490 Ensembl | MGI Sequence Detail 1036 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 55
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146669, MGI:4868747
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 4
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326794 Georgiadou E, et al., Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated beta-Cell Connectivity and Insulin Secretion. Diabetes. 2022 Jul 1;71(7):1472-1489
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory