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Prss56 Gene Detail
Summary
  • Symbol
    Prss56
  • Name
    serine protease 56
  • Synonyms
    1700027L20Rik, Prss56
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916703
    NCBI Gene: 69453
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87111035-87116127 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.07 cM, cytoband C5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916703
 protein coding gene Chr1:87111002-87116127 (+)
129S1/SvImJ ENSMUSG00200037103
 protein coding gene Chr1:84351663-84356755 (+)
A/J ENSMUSG00195029060
 protein coding gene Chr1:83912099-83917192 (+)
AKR/J ENSMUSG00220042114
 protein coding gene Chr1:84030609-84035701 (+)
BALB/cJ ENSMUSG00180014286
 protein coding gene Chr1:84200077-84205169 (+)
C3H/HeJ ENSMUSG00175001345
 protein coding gene Chr1:84086526-84091618 (+)
C57BL/6NJ ENSMUSG00215027561
 protein coding gene Chr1:84001952-84007045 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014374
 protein coding gene Chr1:79661631-79666733 (+)
CAST/EiJ ENSTCUG00005006937
 protein coding gene Chr1:83643922-83649016 (+)
CBA/J ENSMUSG00210012349
 protein coding gene Chr1:83924325-83929417 (+)
DBA/2J ENSMUSG00185016429
 protein coding gene Chr1:88396455-88401547 (+)
FVB/NJ ENSMUSG00205041075
 protein coding gene Chr1:83346145-83351238 (+)
JF1/MsJ ENSUMUG00000013216
 protein coding gene Chr1:87151595-87156688 (+)
LP/J ENSMUSG00230019066
 protein coding gene Chr1:87681217-87686309 (+)
NOD/ShiLtJ ENSMUSG00190021665
 protein coding gene Chr1:83979573-83984665 (+)
NZO/HlLtJ ENSMUSG00225004099
 protein coding gene Chr1:91583928-91589020 (+)
PWK/PhJ ENSLUMG00010044710
 protein coding gene Chr1:83533933-83539026 (+)
SPRET/EiJ ENSMSPG00010041949
 protein coding gene Chr1:85550334-85555437 (+)
WSB/EiJ ENSIUOG00005038367
 protein coding gene Chr1:83574633-83579725 (+)



Homology
more
  • Human Ortholog
    PRSS56, serine protease 56
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS56, serine protease 56
  • Synonyms
    MCOP6
  • Links
    NCBI Gene ID: 646960
    UniProt: P0CW18

  • Chr Location
    2q37.1; chr2:232520388-232525716 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Prss56 mouse models; 1 with human PRSS56 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 5 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU induced mutation show increased intraocular pressure, variable decreases in eye axial length, and narrow iridocorneal angles. Homozygous mice model angle-closure glaucoma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    639
  • Tissues
    28
  • cDNA Data
    6
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036480 Ensembl Gene Model | MGI Sequence Detail 5093 C57BL/6J ±  kb
    transcript ENSMUST00000044533 Ensembl | MGI Sequence Detail 2180 Not Applicable  
    polypeptide ENSMUSP00000138773 Ensembl | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 6
      Primer pair 3
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:378570 Kovaci F, et al., Pharmacological inhibition of RAS pathway alleviates spine deformity in a mouse model of neurofibromatosis type 1. Bone Res. 2025 Dec 16;13(1):103
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory